{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T04:27:45Z","timestamp":1790483265694,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Scottish Prison Service as part of the Scottish Government's Hepatitis C Action Plan for Scotland"},{"name":"MRC Addiction Cluster Grant (NIQUAD)"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>To estimate hepatitis C virus (<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>) incidence and <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> risk among <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>cottish prisoners.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>National sero\u2010behavioural survey; dried blood spots were collected in order to identify recent <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> infections (i.e. <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> antibody\u2010negative and <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> polymerase chain reaction (<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>)\u2010positive).<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>All 14 closed prisons in <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>cotland.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>A total of 5187 prisoners responded to the survey (79% of available prisoners on survey days) comprising 5076 individuals (after removing incomplete returns and participants surveyed in more than one prison); 95% men, 32% (1625) reported an injecting history (<jats:styled-content style=\"fixed-case\">PWID<\/jats:styled-content>) and median sentence of 9.5 months. <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> antibody samples were available for 4904 participants; there was sufficient sera for <jats:styled-content style=\"fixed-case\">HCV PCR<\/jats:styled-content> for 2446 prisoners who had been in prison for at least 75 days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements<\/jats:title><jats:p>The estimate of in\u2010prison recent infections is based on prisoners incarcerated for a sufficient period, i.e. at least 75 days, so that recent infections could be attributed to prison.<\/jats:p><\/jats:sec><jats:sec><jats:title>Findings<\/jats:title><jats:p>Overall <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> prevalence was 19%; 53% among people who reported an injecting history and 3% among other prisoners. Three recent infections probably acquired in prison were detected. None of the cases reported injecting during their current sentence or any other potential exposure. Estimated incidence was 0.6\u20130.9% overall and 3.0\u20134.3% among <jats:styled-content style=\"fixed-case\">PWID<\/jats:styled-content> (assuming all infections acquired through injecting). Fifty\u2010seven per cent (929) of <jats:styled-content style=\"fixed-case\">PWID<\/jats:styled-content> were receiving opiate substitution treatment (<jats:styled-content style=\"fixed-case\">OST<\/jats:styled-content>) at the time of the survey. Of all prisoners, 2.5% and 8% of <jats:styled-content style=\"fixed-case\">PWID<\/jats:styled-content> reported injecting during their current period of incarceration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The low incidence of <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> infections in <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>cottish prisons is due most probably to the low occurrence of in\u2010prison injecting and high coverage of <jats:styled-content style=\"fixed-case\">OST<\/jats:styled-content>. Low <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> risk can be achieved in prisons without necessarily introducing needle exchange programmes, but close monitoring of risk behaviours is essential. 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