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This study aimed to replicate these results by comparing bupropion versus placebo in methamphetamine\u2010dependent participants with less than daily methamphetamine use at baseline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Methamphetamine\u2010dependent volunteers reporting methamphetamine use on \u226429 of past 30 days were randomized to bupropion 150\u2009mg twice daily (<jats:italic>n<\/jats:italic>\u2009=\u200941) or placebo (<jats:italic>n<\/jats:italic>\u2009=\u200943) and out\u2010patient counseling for 12 weeks. The primary outcome was the proportion achieving end\u2010of\u2010treatment (<jats:styled-content style=\"fixed-case\">EOT<\/jats:styled-content>) methamphetamine abstinence (weeks 11 and 12) for bupropion versus placebo. A <jats:italic>post\u2010hoc<\/jats:italic> analysis compared <jats:styled-content style=\"fixed-case\">EOT<\/jats:styled-content> abstinence by medication adherence assessed via plasma bupropion\/hydroxybupropion level.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was no significant difference in <jats:styled-content style=\"fixed-case\">EOT<\/jats:styled-content> abstinence between bupropion (29%, 12 of 41) and placebo (14%, six of 43; <jats:italic>P<\/jats:italic>\u2009=\u20090.087). Among participants receiving bupropion, <jats:styled-content style=\"fixed-case\">EOT<\/jats:styled-content> abstinence was significantly higher in participants assessed as medication adherent by plasma bupropion\/hydroxybupropion levels (54%, seven of 13) compared to non\u2010adherent participants (18%, five of 28; <jats:italic>P<\/jats:italic>\u2009=\u20090.018). Medication adherence by plasma levels was low (32%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Bupropion may be efficacious for reducing methamphetamine in people with less than daily baseline methamphetamine use, but the evidence remains inconclusive.<\/jats:p><\/jats:sec>","DOI":"10.1111\/add.12636","type":"journal-article","created":{"date-parts":[[2014,6,4]],"date-time":"2014-06-04T10:48:46Z","timestamp":1401878926000},"page":"1878-1886","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Randomized, placebo\u2010controlled trial of bupropion in methamphetamine\u2010dependent participants with less than daily methamphetamine use"],"prefix":"10.1111","volume":"109","author":[{"given":"Keith G.","family":"Heinzerling","sequence":"first","affiliation":[{"name":"University of California Los Angeles (UCLA) Department of Family Medicine UCLA Center for Behavioral and Addiction Medicine  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