{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T03:18:50Z","timestamp":1786591130111,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,11,13]],"date-time":"2014-11-13T00:00:00Z","timestamp":1415836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2014,11,13]],"date-time":"2014-11-13T00:00:00Z","timestamp":1415836800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"name":"US National Institute on Alcohol Abuse and Alcoholism (NIAAA)","award":["RO1 2 AA013750-04"],"award-info":[{"award-number":["RO1 2 AA013750-04"]}]},{"DOI":"10.13039\/100000027","name":"NIAAA","doi-asserted-by":"crossref","award":["AA 005595"],"award-info":[{"award-number":["AA 005595"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction"],"published-print":{"date-parts":[[2015,2]]},"abstract":"Abstract<\/jats:title>\n \n Aims<\/jats:title>\n To update and extend analysis of the dose\u2013response relationship of injury and drinking by demographic and injury subgroups and country\u2010level drinking pattern, and examine the validity and efficiency of the fractional polynomial approach to modeling this relationship.<\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n Pair\u2010matched case\u2013cross\u2010over analysis of drinking prior to injury, using categorical step\u2010function and fractional polynomial analysis.<\/jats:p>\n <\/jats:sec>\n \n Setting<\/jats:title>\n \n Thirty\u2010seven emergency departments (\n ED<\/jats:styled-content>\n s) across 18 countries.\n <\/jats:p>\n <\/jats:sec>\n \n Participants<\/jats:title>\n \n A total of 13\u2009119 injured drinkers arriving at the\n ED<\/jats:styled-content>\n within 6 hours of the event.\n <\/jats:p>\n <\/jats:sec>\n \n Measurements<\/jats:title>\n \n The dose\u2013response relationship was analyzed by gender, age, cause of injury (traffic, violence, fall, other) and country detrimental drinking pattern (\n DDP<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Findings<\/jats:title>\n \n Estimated risks were similar between the two analytical methods, with injury risk doubling at one drink [odds ratio (\n OR<\/jats:styled-content>\n )\u2009=\u20092.3\u20132.7] and peaking at about 30 drinks. Although risk was similar for males and females up to three drinks (\n OR<\/jats:styled-content>\n \u2009=\u20094.6), it appeared to increase more rapidly for females and was significantly higher starting from 20 drinks [female\n OR<\/jats:styled-content>\n \u2009=\u200928.6; confidence interval (\n CI<\/jats:styled-content>\n )<\/jats:styled-content>\n \u2009=\u200916.8, 48.9; male\n OR<\/jats:styled-content>\n \u2009=\u200912.8;\n CI<\/jats:styled-content>\n \u2009=\u200910.1, 16.3]. No significant differences were found across age groups. Risk was significantly higher for violence\u2010related injury than for other causes across the volume range. Risk was also higher at all volumes for\n DDP<\/jats:styled-content>\n \u20103 compared with\n DDP<\/jats:styled-content>\n \u20102 countries.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n There is an increasing risk relationship between alcohol and injury but risk is not uniform across gender, cause of injury or country drinking pattern. The fractional polynomial approach is a valid and efficient approach for modeling the alcohol injury risk relationship.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/add.12755","type":"journal-article","created":{"date-parts":[[2014,10,30]],"date-time":"2014-10-30T02:46:42Z","timestamp":1414637202000},"page":"279-288","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":74,"title":["Relative risk of injury from acute alcohol consumption: modeling the dose\u2013response relationship in emergency department data from 18 countries"],"prefix":"10.1111","volume":"110","author":[{"given":"Cheryl J.","family":"Cherpitel","sequence":"first","affiliation":[{"name":"Statistical and Data Services Department Alcohol Research Group Emeryville CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Ye","sequence":"additional","affiliation":[{"name":"Statistical and Data Services Department Alcohol Research Group Emeryville CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Bond","sequence":"additional","affiliation":[{"name":"Statistical and Data Services Department Alcohol Research Group Emeryville CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilherme","family":"Borges","sequence":"additional","affiliation":[{"name":"Universidad Autonoma Metropolitana Instituto Nacional de Psiquiatria Mexico Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maristela","family":"Monteiro","sequence":"additional","affiliation":[{"name":"Substance Abuse Pan American Health Organization Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,11,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61766-8"},{"key":"e_1_2_6_3_1","volume-title":"Global Burden of Diseases, Injuries, and Risk Factors Study 2010 (GBD 2010)","author":"Institute for Health Metrics and Evaluation","year":"2013"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1360-0443.1999.9410155111.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2012.01919.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2010.02.011"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.05.027466"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/28.5.964"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1986.10478350"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a116520"},{"key":"e_1_2_6_11_1","volume-title":"Global Strategy to Reduce the Harmful Use of Alcohol","author":"World Health Organization","year":"2010"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/oso\/9780192632616.001.0001"},{"key":"e_1_2_6_13_1","volume-title":"Prevention of Alcohol\u2010Related Injuries in the Americas: From Evidence to Policy Action","author":"Cherpitel C. 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