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The Short Form Health Survey and Quality of Life measures were used to assess pain interference and pain intensity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Findings<\/jats:title>\n                    <jats:p>\n                      Pain was a significant predictor of heavy drinking lapses during treatment in UKATT [odds ratio (OR)\u2009=\u20091.19, 95% confidence interval (CI)\u2009=\u20091.08, 1.32,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.0003] and COMBINE (OR\u2009=\u20091.12, 95% CI\u2009=\u20091.03, 1.21,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.009), and was a significant predictor of heavy drinking lapses following treatment in COMBINE (OR\u2009=\u20091.163, 95% CI\u2009=\u20091.15, 1.17,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.00001). After controlling for other relapse risk factors (e.g. dependence severity, self\u2010efficacy, temptation, psychiatric distress), pain remained a significant predictor of heavy drinking lapses during treatment in UKATT (OR\u2009=\u20091.19, 95% CI\u2009=\u20091.06, 1.34,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.004) and following treatment in COMBINE (OR\u2009=\u20091.44, 95% CI\u2009=\u20091.07, 1.92,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Among people treated for alcohol use disorder, being in physical pain appears to predict heavy drinking lapses during or after treatment.<\/jats:p>\n                  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