{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T02:29:15Z","timestamp":1790648955238,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,9,22]],"date-time":"2015-09-22T00:00:00Z","timestamp":1442880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"RETICS Scheme of the Instituto de Salud Carlos III","award":["RD12\/0028\/0017"],"award-info":[{"award-number":["RD12\/0028\/0017"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>To contrast functional connectivity on ventral and dorsal striatum networks in cocaine dependence relative to pathological gambling, via a resting\u2010state functional connectivity approach; and to determine the association between cocaine dependence\u2010related neuroadaptations indexed by functional connectivity and impulsivity, compulsivity and drug relapse.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Cross\u2010sectional study of 20 individuals with cocaine dependence (CD), 19 individuals with pathological gambling (PG) and 21 healthy controls (HC), and a prospective cohort study of 20 CD followed\u2010up for 12 weeks to measure drug relapse.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting and Participants<\/jats:title><jats:p>CD and PG were recruited through consecutive admissions to a public clinic specialized in substance addiction treatment (Centro Provincial de Drogodependencias) and a public clinic specialized in gambling treatment (AGRAJER), respectively; HC were recruited through community advertisement in the same area in Granada (Spain).<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements<\/jats:title><jats:p>Seed\u2010based functional connectivity in the ventral striatum (ventral caudate and ventral putamen) and dorsal striatum (dorsal caudate and dorsal putamen), the Kirby delay\u2010discounting questionnaire, the reversal\u2010learning task and a dichotomous measure of cocaine relapse indicated with self\u2010report and urine tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Findings<\/jats:title><jats:p>CD relative to PG exhibit enhanced connectivity between the ventral caudate seed and subgenual anterior cingulate cortex, the ventral putamen seed and dorsomedial pre\u2010frontal cortex and the dorsal putamen seed and insula (<jats:italic>P<\/jats:italic>\u2009\u2264\u20090.001, kE\u2009=\u2009108). Connectivity between the ventral caudate seed and subgenual anterior cingulate cortex is associated with steeper delay discounting (<jats:italic>P<\/jats:italic>\u2009\u2264\u20090.001, kE\u2009=\u2009108) and cocaine relapse (<jats:italic>P<\/jats:italic>\u2009\u2264\u20090.005, kE\u2009=\u200934).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Cocaine dependence\u2010related neuroadaptations in the ventral striatum of the brain network are associated with increased impulsivity and higher rate of cocaine relapse.<\/jats:p><\/jats:sec>","DOI":"10.1111\/add.13076","type":"journal-article","created":{"date-parts":[[2015,7,25]],"date-time":"2015-07-25T12:08:49Z","timestamp":1437826129000},"page":"1953-1962","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Cocaine\u2010specific neuroplasticity in the ventral striatum network is linked to delay discounting and drug relapse"],"prefix":"10.1111","volume":"110","author":[{"given":"Oren","family":"Contreras\u2010Rodr\u00edguez","sequence":"first","affiliation":[{"name":"Red de Trastornos Adictivos Universidad de Granada  Granada Spain"},{"name":"Institute of Neuroscience F. Oloriz Universidad de Granada  Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Albein\u2010Urios","sequence":"additional","affiliation":[{"name":"Cognitive Neuroscience Unit Deakin University  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 C.","family":"Perales","sequence":"additional","affiliation":[{"name":"Red de Trastornos Adictivos Universidad de Granada  Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 M.","family":"Mart\u00ednez\u2010Gonzalez","sequence":"additional","affiliation":[{"name":"Red de Trastornos Adictivos Universidad de Granada  Granada Spain"},{"name":"Centro Provincial de Drogodependencias Diputaci\u00f3n de Granada  Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Vilar\u2010L\u00f3pez","sequence":"additional","affiliation":[{"name":"Red de Trastornos Adictivos Universidad de Granada  Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda J.","family":"Fern\u00e1ndez\u2010Serrano","sequence":"additional","affiliation":[{"name":"Red de Trastornos Adictivos Universidad de Granada  Granada Spain"},{"name":"Department of Psychology Universidad de Ja\u00e9n  Ja\u00e9n Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar","family":"Lozano\u2010Rojas","sequence":"additional","affiliation":[{"name":"Red de Trastornos Adictivos Universidad de Granada  Granada Spain"},{"name":"School of Psychology Universidad de Huelva  Huelva Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Verdejo\u2010Garc\u00eda","sequence":"additional","affiliation":[{"name":"Red de Trastornos Adictivos Universidad de Granada  Granada Spain"},{"name":"Institute of Neuroscience F. 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