{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T03:58:45Z","timestamp":1780977525690,"version":"3.54.1"},"reference-count":54,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,11,25]],"date-time":"2015-11-25T00:00:00Z","timestamp":1448409600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2015,11,25]],"date-time":"2015-11-25T00:00:00Z","timestamp":1448409600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To estimate adherence and response to therapy for chronic hepatitis C virus (HCV) infection among people with a history of injecting drug use. A secondary aim was to identify predictors of HCV treatment response.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Prospective cohort recruited between 2009 and 2012. Participants were treated with peg\u2010interferon alfa\u20102a\/ribavirin for 24 (genotypes 2\/3, G2\/3) or 48\u2009weeks (genotype 1, G1).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Six opioid substitution treatment (OST) clinics, two community health centres and one Aboriginal community\u2010controlled health organization providing drug treatment services in New South Wales, Australia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>Among 415 people with a history of injecting drug use and chronic HCV assessed by a nurse, 101 were assessed for treatment outcomes (21% female).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements<\/jats:title>\n                    <jats:p>\n                      Study outcomes were treatment adherence and sustained virological response (SVR, undetectable HCV RNA\n                      <jats:styled-content>&gt;<\/jats:styled-content>\n                      24\u2009weeks post\u2010treatment).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Findings<\/jats:title>\n                    <jats:p>\n                      Among 101 treated, 37% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200937) had recently injected drugs (past 6\u2009months) and 62% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200963) were receiving OST. Adherence \u2265\u200980% was 86% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200987). SVR was 74% (75 of 101), with no difference observed by sex (males: 76%, females: 67%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.662). In adjusted analysis, age &lt;\u200935 (versus \u2265\u200945\u2009years) [adjusted odds ratio (aOR)\u2009=\u20095.06, 95% confidence interval (CI)\u2009=\u20091.47, 17.40] and on\u2010treatment adherence \u2265\u200980% independently predicted SVR (aOR\u2009=\u200919.41, 95% CI\u2009=\u20093.61, 104.26]. Recent injecting drug use at baseline was not associated with SVR.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>People with a history of injecting drug use and chronic hepatitis C virus attending opioid substitution treatment and community health clinics can achieve adherence and responses to interferon\u2010based therapy similar to other populations, despite injecting drugs at baseline. Younger age and adherence are predictive of improved response to hepatitis C virus therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/add.13197","type":"journal-article","created":{"date-parts":[[2015,10,9]],"date-time":"2015-10-09T09:44:46Z","timestamp":1444383886000},"page":"311-319","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":63,"title":["Treatment for hepatitis C virus infection among people who inject drugs attending opioid substitution treatment and community health clinics: the ETHOS Study"],"prefix":"10.1111","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1833-2017","authenticated-orcid":false,"given":"Jason","family":"Grebely","sequence":"first","affiliation":[{"name":"The Kirby Institute UNSW Australia  Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Alavi","sequence":"additional","affiliation":[{"name":"The Kirby 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