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Utility is a numerical representation of health\u2010related quality of life used in economic evaluations to \u2018adjust\u2019 estimated survival to include peoples\u2019 preferences for health states. Utilities are determined by surveying the general population to estimate the value they assign to particular health states on a scale where 0\u00a0=\u00a0the value of being dead and 1.0\u00a0=\u00a0the value of being in perfect health. Spouse spillover utility is assigned to a spouse of an individual who is in a particular health state.<\/jats:p><\/jats:sec><jats:sec><jats:title>Findings<\/jats:title><jats:p>Mean individual utility ranged from 0.574 [95%\u00a0confidence interval (CI)\u00a0=\u00a00.538, 0.611] for active injection opioid misuse to 0.766 for stabilized buprenorphine therapy (95% CI\u00a0=\u00a00.738, 0.795), with other states in between. Female respondents assigned higher utility to the active prescription misuse and buprenorphine therapy at initiation states than did males (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05); all other states did not differ by respondent gender. Mean spousal utilities were significantly lower than 1.0 but mostly higher than individual utility, and were similar between male and female respondents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In the opinion of the US public, injection opioid misuse results in worse health\u2010related quality of life than prescription misuse, and methadone therapy results in worse health\u2010related quality of life than buprenorphine therapy. Spouses are negatively affected by their partner's opioid misuse and early treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/add.13219","type":"journal-article","created":{"date-parts":[[2015,10,24]],"date-time":"2015-10-24T15:13:54Z","timestamp":1445699634000},"page":"675-684","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Measuring benefits of opioid misuse treatment for economic evaluation: health\u2010related quality of life of opioid\u2010dependent individuals and their spouses as assessed by a sample of the US population"],"prefix":"10.1111","volume":"111","author":[{"given":"Eve","family":"Wittenberg","sequence":"first","affiliation":[{"name":"Center for Health Decision Science Harvard T.H. 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