{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:55:28Z","timestamp":1790787328530,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,2,14]],"date-time":"2017-02-14T00:00:00Z","timestamp":1487030400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","award":["PSI2013\u201045055\u2010P"],"award-info":[{"award-number":["PSI2013\u201045055\u2010P"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007136","name":"Secretar\u00eda de Estado de Investigaci\u00f3n, Desarrollo e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["PSI2013\u201045055\u2010P"],"award-info":[{"award-number":["PSI2013\u201045055\u2010P"]}],"id":[{"id":"10.13039\/501100007136","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007136","name":"Secretar\u00eda de Estado de Investigaci\u00f3n, Desarrollo e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["PSI2013\u201045055\u2010P"],"award-info":[{"award-number":["PSI2013\u201045055\u2010P"]}],"id":[{"id":"10.13039\/501100007136","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>Gambling disorder is characterized by poor regulation of negative emotions and impulsive behaviours. This study aimed to (1) compare gambling disorder patients (GDPs) and healthy controls (HCs) in self\u2010report and brain activation measures of emotion regulation; and (2) establish its relationship with negative emotion\u2010driven impulsivity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Two cross\u2010sectional case\u2013control studies including GDPs and HCs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting and Participants<\/jats:title><jats:p>GDPs and HCs were recruited from specialized gambling clinics in Andalusia (Spain), where they were following out\u2010patient treatment, and from the community, respectively. Study 1 included 41 GDPs and 45 HCs [All males; M<jats:sub>age<\/jats:sub>\u00a0=\u00a035.22, 33.22; standard deviation (SD)\u00a0=\u00a011.16, 8.18; respectively]. Study 2 included 17 GDPs and 21 HCs (16\/20 males; M<jats:sub>age<\/jats:sub>\u00a0=\u00a032.94, 31.00; SD\u00a0=\u00a07.77, 4.60; respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements<\/jats:title><jats:p>In study 1, we compared both groups on suppression and re\u2010appraisal emotion regulation strategies [Emotion Regulation Questionnaire (ERQ)]. In study 2, we compared GDPs with HCs on brain activation associated with down\u2010regulation of negative emotions in a cognitive re\u2010appraisal task, measured with functional magnetic resonance imaging (fMRI). In both studies, we correlated the measures of emotion regulation with mood\u2010related impulsivity indicated by negative urgency (UPPS\u2010P impulsive behaviour scale).<\/jats:p><\/jats:sec><jats:sec><jats:title>Findings<\/jats:title><jats:p>GDPs relative to HCs showed higher levels of emotional suppression [<jats:italic>F<\/jats:italic>\u00a0=\u00a04.525; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.036; means difference M<jats:sub>HCs<\/jats:sub>\u2013M<jats:sub>GDPs<\/jats:sub>\u00a0=\u00a0\u22122.433, 95% confidence interval (CI)\u00a0=\u00a0\u22124.706, \u22120.159] and higher activation of the premotor cortex and middle frontal gyrus during negative emotion regulation in the fMRI task [<jats:italic>P<\/jats:italic>\u00a0\u2264\u00a00.005, cluster size (CS)\u00a0&gt;\u00a050 voxels]. Negative urgency correlated positively with emotional suppression (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.399, 95% CI\u00a0=\u00a00.104, 0.629, one\u2010tailed <jats:italic>P<\/jats:italic>\u00a0=\u00a00.005) and middle frontal gyrus activation during negative emotion regulation (<jats:italic>P<\/jats:italic>\u00a0\u2264\u00a00.005, CS\u00a0&gt;\u00a050) in GDPs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Gambling disorder is associated with greater use of emotional suppression and stronger pre\u2010motor cortex and middle frontal gyrus activation for regulating negative emotions, compared with healthy controls. Emotional suppression use and middle frontal gyrus activation during negative emotion regulation are linked with negative emotion\u2010driven impulsivity in this disorder.<\/jats:p><\/jats:sec>","DOI":"10.1111\/add.13751","type":"journal-article","created":{"date-parts":[[2017,1,6]],"date-time":"2017-01-06T18:02:39Z","timestamp":1483725759000},"page":"1086-1094","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":83,"title":["Trait and neurobiological underpinnings of negative emotion regulation in gambling disorder"],"prefix":"10.1111","volume":"112","author":[{"given":"Juan F.","family":"Navas","sequence":"first","affiliation":[{"name":"Department of Experimental Psychology University of Granada  Granada Spain"},{"name":"Mind, Brain and Behavior Research Center (CIMCYC) University of Granada  Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oren","family":"Contreras\u2010Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Bellvitge Biomedical Research Institute  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Verdejo\u2010Rom\u00e1n","sequence":"additional","affiliation":[{"name":"Mind, Brain and Behavior Research Center (CIMCYC) University of Granada  Granada Spain"},{"name":"Department of Personality, Assessment and Clinical Treatment University of Granada  Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Perandr\u00e9s\u2010G\u00f3mez","sequence":"additional","affiliation":[{"name":"Mind, Brain and Behavior Research Center (CIMCYC) University of Granada  Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Albein\u2010Urios","sequence":"additional","affiliation":[{"name":"School of Psychology, Cognitive Neuroscience Unit Deakin University  Burwood Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Verdejo\u2010Garc\u00eda","sequence":"additional","affiliation":[{"name":"Monash Institute of Cognitive and Clinical Neurosciences and School of Psychological Sciences Monash University  Melbourne Australia"},{"name":"Red de trastornos adictivos University of Granada  Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 C.","family":"Perales","sequence":"additional","affiliation":[{"name":"Department of Experimental Psychology University of Granada  Granada Spain"},{"name":"Mind, Brain and Behavior Research Center (CIMCYC) University of Granada  Granada Spain"},{"name":"Red de trastornos adictivos University of Granada  Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,2,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-011-2550-7"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2013.03.004"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1360-0443.2002.00015.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-7358(00)00087-8"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/02024458-201509000-00009"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1037\/0022-3514.85.2.348"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn4044"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2009.11.004"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnsys.2014.00175"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2044-8260.2011.02022.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1556\/2006.5.2016.040"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bht154"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.11.001"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1369-1600.2012.00497.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2010.04.005"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.paid.2007.02.008"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/add.13641"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1017\/S003329171100095X"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2013.00043"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2012.01.001"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0013341"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2016.02.024"},{"key":"e_1_2_7_25_1","volume-title":"Wechsler adult intelligence scale \u2010 Fourth Edition (WAIS\u2010IV)","author":"Wechsler D.","year":"2008"},{"key":"e_1_2_7_26_1","first-page":"769","article-title":"Cuestionario de juego patol\u00f3gico de South Oaks (SOGS): Validaci\u00f3n Espa\u00f1ola [The South Oaks Gambling Screen (SOGS): Spanish validation]","volume":"20","author":"Echebur\u00faa E.","year":"1994","journal-title":"An\u00e1l Modif Conduct"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.144.9.1184"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1575-0973(07)75656-8"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1575-0973(12)70048-X"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1027\/1015-5759\/a000150"},{"key":"e_1_2_7_31_1","volume-title":"Structured Clinical Interview for DSM\u2010IV\u2010TR Axis I Disorders (SCID I)","author":"Michael B. F.","year":"1997"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1994.03950030051005"},{"key":"e_1_2_7_33_1","volume-title":"Kaufman Brief Intelligence Test","author":"Kaufman A.","year":"1990"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1080\/00223890903382369"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2004.10.030"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1080\/026999399379186"},{"key":"e_1_2_7_37_1","unstructured":"LangP. BradleyM. CuthbertB.International Affective Picture System (IAPS): Technical Manual and Affective Ratings. Technical Report A\u20105. Gainesville FL: University of Florida Center for Research in Psychophysiology;2001."},{"key":"e_1_2_7_38_1","first-page":"55","article-title":"Un m\u00e9todo para el estudio experimental de las emociones: el International Affective Picture System (IAPS). Adaptaci\u00f3n espa\u00f1ola [A method for experimental study of emotions: the International Affective Picture System (IAPS). Spanish validation]","volume":"52","author":"Molt\u00f3 J.","year":"1999","journal-title":"Rev Psicol Gen Apl"},{"key":"e_1_2_7_39_1","volume-title":"Using Multivariate Statistics","author":"Tabachnick B. G.","year":"2013"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.12.058"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0025031"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/1467-9280.00250"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2009.07.007"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0050647"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0030909"}],"container-title":["Addiction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fadd.13751","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/add.13751","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/add.13751","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/add.13751","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T08:49:21Z","timestamp":1693212561000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/add.13751"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,14]]},"references-count":44,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["10.1111\/add.13751"],"URL":"https:\/\/doi.org\/10.1111\/add.13751","archive":["Portico"],"relation":{},"ISSN":["0965-2140","1360-0443"],"issn-type":[{"value":"0965-2140","type":"print"},{"value":"1360-0443","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,14]]},"assertion":[{"value":"2016-08-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-01-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-02-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}