{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T19:31:37Z","timestamp":1792092697027,"version":"4.4.0"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,10,12]],"date-time":"2017-10-12T00:00:00Z","timestamp":1507766400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["R01\/AA016834"],"award-info":[{"award-number":["R01\/AA016834"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and aims<\/jats:title><jats:p>The nicotinic acetylcholine receptor antagonist, mecamylamine, is a potential novel pharmacotherapy for alcohol use disorder. The aims were to compare alcohol consumption between mecamylamine and placebo and test if smoking status modified treatment effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Out\u2010patient, randomized, double\u2010blind clinical trial for 12\u00a0weeks of treatment with mecamylamine (10\u00a0mg) (<jats:italic>n<\/jats:italic>\u00a0=\u00a065) versus placebo (<jats:italic>n<\/jats:italic>\u00a0=\u00a063).<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Connecticut, USA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>Individuals had current alcohol dependence (<jats:italic>n<\/jats:italic>\u00a0=\u00a0128), had an average age of 48.5 [standard deviation (SD)\u00a0=\u00a09.4], 110 (85.9%) were men, and included 74 smokers (57.8%) and 54 non\u2010smokers (42.2%). Participants were randomized to mecamylamine 10\u00a0mg per day or placebo. All subjects also received medical management therapy administered by trained research personnel.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements<\/jats:title><jats:p>Primary outcome was percentage of heavy drinking days during the last month of treatment; other outcomes included drinking days, drinks per drinking days, alcohol craving, smoking, symptoms of nicotine withdrawal and side effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Findings<\/jats:title><jats:p>There were no significant differences in the percentage of heavy drinking days at 3\u00a0months between the mecamylamine (mean\u00a0=\u00a018.4, SD\u00a0=\u00a029.0) and placebo treatment groups (mean\u00a0=\u00a020.4, SD\u00a0=\u00a029.2) [<jats:italic>F<\/jats:italic><jats:sub>1, 100<\/jats:sub>\u00a0=\u00a01.3,<jats:italic>P<\/jats:italic>\u00a0=\u00a00.25; effect size<jats:italic>d<\/jats:italic>\u00a0=\u00a00.07; mean difference\u00a0=\u00a02.06, 95% confidence interval (CI)\u00a0=\u00a0\u22128.96 to 13.08]. There were no significant differences in percentage of drinking days or in drinks per drinking day at month 3 between the mecamylamine and placebo groups; there were no significant interactions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Mecamylamine 10\u00a0mg per day did not reduce alcohol consumption significantly in treatment\u2010seeking smokers and non\u2010smokers with alcohol use disorder.<\/jats:p><\/jats:sec>","DOI":"10.1111\/add.13943","type":"journal-article","created":{"date-parts":[[2017,7,15]],"date-time":"2017-07-15T12:26:37Z","timestamp":1500121597000},"page":"6-14","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Mecamylamine treatment for alcohol dependence: a randomized controlled trial"],"prefix":"10.1111","volume":"113","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6894-5946","authenticated-orcid":false,"given":"Ismene L.","family":"Petrakis","sequence":"first","affiliation":[{"name":"VISN I Mental Illness Research Education Clinical Center (MIRECC) West Haven CT USA"},{"name":"VA Connecticut Healthcare System West Haven CT USA"},{"name":"Department of Psychiatry Yale University School of Medicine New Haven CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Ralevski","sequence":"additional","affiliation":[{"name":"VISN I Mental Illness Research Education Clinical Center (MIRECC) West Haven CT USA"},{"name":"VA Connecticut Healthcare System West Haven CT USA"},{"name":"Department of Psychiatry Yale University School of Medicine New Haven CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralitza","family":"Gueorguieva","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Yale University School of Medicine New Haven CT USA"},{"name":"Department of Biostatistics Yale University School of Public Health New Haven CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie S.","family":"O'Malley","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Yale University School of Medicine New Haven CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Arias","sequence":"additional","affiliation":[{"name":"VISN I Mental Illness Research Education Clinical Center (MIRECC) West Haven CT USA"},{"name":"VA Connecticut Healthcare System West Haven CT USA"},{"name":"Department of Psychiatry Yale University School of Medicine New Haven CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin A.","family":"Sevarino","sequence":"additional","affiliation":[{"name":"VISN I Mental Illness Research Education Clinical Center (MIRECC) West Haven CT USA"},{"name":"VA Connecticut Healthcare System West Haven CT USA"},{"name":"Department of Psychiatry Yale University School of Medicine New Haven CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane S.","family":"Jane","sequence":"additional","affiliation":[{"name":"VISN I Mental Illness Research Education Clinical Center (MIRECC) West Haven CT USA"},{"name":"VA Connecticut Healthcare System West Haven CT USA"},{"name":"Department of Psychiatry Yale University School of Medicine New Haven CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin","family":"O'Brien","sequence":"additional","affiliation":[{"name":"VISN I Mental Illness Research Education Clinical Center (MIRECC) West Haven CT USA"},{"name":"VA Connecticut Healthcare System West Haven CT USA"},{"name":"Department of Psychiatry Yale University School of Medicine New Haven CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John H.","family":"Krystal","sequence":"additional","affiliation":[{"name":"VA Connecticut Healthcare System West Haven CT USA"},{"name":"Department of Psychiatry Yale University School of Medicine New Haven CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,10,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.3628"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/add.12875"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1176\/ps.2010.61.4.392"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.2174\/187152710790966597"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.61.11.1107"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0034538"},{"key":"e_1_2_7_8_1","first-page":"172","article-title":"Co\u2010occurring risk factors for alcohol dependence and habitual smoking: update on findings from the collaborative study on the genetics of alcoholism","volume":"29","author":"Grucza R. 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