{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T10:27:04Z","timestamp":1790677624730,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,7,10]],"date-time":"2018-07-10T00:00:00Z","timestamp":1531180800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Cancer Insitute","award":["P30 CA015083"],"award-info":[{"award-number":["P30 CA015083"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>To measure carbonyl emissions from a heated tobacco product (IQOS) in comparison with an e\u2010cigarette (Nautilus Mini) and a commercial tobacco cigarette (Marlboro Red).<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Regular and menthol variants of the heated tobacco product were tested. A tank\u2010type atomizer was tested with a tobacco\u2010flavoured liquid at 10 and 14\u00a0W. Aerosol and smoke were collected in impingers containing 2,4\u2010dinitrophenylhydrazine. Health Canada Intense and two more intense puffing regimens were used.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Analytical laboratory in Greece.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements<\/jats:title><jats:p>Carbonyl levels in the aerosol and smoke.<\/jats:p><\/jats:sec><jats:sec><jats:title>Findings<\/jats:title><jats:p>At the Health Canada Intense regimen, heated tobacco products emitted 5.0\u20136.4\u00a0\u03bcg\/stick formaldehyde, 144.1\u2013176.7\u00a0\u03bcg\/stick acetaldehyde, 10.4\u201310.8\u00a0\u03bcg\/stick acrolein, 11.0\u201312.8\u00a0\u03bcg\/stick propionaldehyde and 1.9\u20132.0\u00a0\u03bcg\/stick crotonaldehyde. Compared with the tobacco cigarette, levels were on average 91.6% lower for formaldehyde, 84.9% lower for acetaldehyde, 90.6% lower for acrolein, 89.0% lower for propionaldehyde and 95.3% lower for crotonaldehyde. The e\u2010cigarette emitted 0.5\u20131.0\u00a0\u03bcg\/12 puffs formaldehyde, 0.8\u20131.5\u00a0\u03bcg\/12 puffs acetaldehyde and 0.3\u20130.4\u00a0\u03bcg\/12 puffs acrolein, but no propionaldehyde and crotonaldehyde. At more intense puffing regimens, formaldehyde was increased in heated tobacco products, but levels were three\u2013fourfold lower compared with the tobacco cigarette. Based on the findings from Health Canada Intense puffing regimen, use of 20 heated tobacco sticks would result in approximately 85% to 95% reduced carbonyl exposure compared with smoking 20 tobacco cigarettes; the respective reduction in exposure from use of 5\u00a0g e\u2010cigarette liquid would be 97% to &gt; 99%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The IQOS heated tobacco product emits substantially lower levels of carbonyls than a commercial tobacco cigarette (Marlboro Red) but higher levels than a Nautilus Mini e\u2010cigarette.<\/jats:p><\/jats:sec>","DOI":"10.1111\/add.14365","type":"journal-article","created":{"date-parts":[[2018,6,19]],"date-time":"2018-06-19T20:16:54Z","timestamp":1529439414000},"page":"2099-2106","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":124,"title":["Carbonyl emissions from a novel heated tobacco product (IQOS): comparison with an e\u2010cigarette and a tobacco cigarette"],"prefix":"10.1111","volume":"113","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6839-4710","authenticated-orcid":false,"given":"Konstantinos E.","family":"Farsalinos","sequence":"first","affiliation":[{"name":"Department of Cardiology Onassis Cardiac Surgery Center  Kallithea Greece"},{"name":"Department of Pharmacy University of Patras  Rio\u2010Patras Greece"},{"name":"National School of Public Health  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikoletta","family":"Yannovits","sequence":"additional","affiliation":[{"name":"Skylab\u2010Med Laboratories of Applied Industrial Research and Analysis SA  Marousi Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theoni","family":"Sarri","sequence":"additional","affiliation":[{"name":"Skylab\u2010Med Laboratories of Applied Industrial Research and Analysis SA  Marousi Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vassilis","family":"Voudris","sequence":"additional","affiliation":[{"name":"Department of Cardiology Onassis Cardiac Surgery Center  Kallithea Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Poulas","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University of Patras  Rio\u2010Patras Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott J.","family":"Leischow","sequence":"additional","affiliation":[{"name":"Arizona College of Health Solutions Arizona State University  Phoenix AZ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,7,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.48.4.385"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002130050719"},{"key":"e_1_2_7_4_1","unstructured":"U.S Department of Health and Human Services US Food and Drug Administration. 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