{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T10:49:33Z","timestamp":1792838973771,"version":"4.5.0"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,9,21]],"date-time":"2018-09-21T00:00:00Z","timestamp":1537488000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2018,9,21]],"date-time":"2018-09-21T00:00:00Z","timestamp":1537488000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"name":"National Heart Foundation Future Leader Fellowship","award":["100411"],"award-info":[{"award-number":["100411"]}]},{"name":"Australian National Health and Medical Research Council Project","award":["1028543"],"award-info":[{"award-number":["1028543"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction"],"published-print":{"date-parts":[[2019,2]]},"abstract":"Abstract<\/jats:title>\n \n Aims<\/jats:title>\n \n To estimate the prevalence of exposure to acamprosate in pregnancy in New South Wales (NSW), Australia, to compare the maternal health of women exposed to acamprosate during pregnancy with non\u2010exposed women, and to compare neonatal outcomes in neonates exposed to acamprosate\n in utero<\/jats:italic>\n with non\u2010exposed neonates.\n <\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n A population\u2010based retrospective cohort study, comparing maternal and neonatal health outcomes in women exposed to acamprosate during pregnancy with women with a recent history of problematic alcohol use (alcohol comparison group), and women from the general community (community comparison group) using state\u2010wide linked health data.<\/jats:p>\n <\/jats:sec>\n \n Setting<\/jats:title>\n New South Wales, Australia.<\/jats:p>\n <\/jats:sec>\n \n Participants<\/jats:title>\n \n The study included women treated with acamprosate for more than 30\u00a0days during pregnancy between 2003 and 2012 (\n n<\/jats:italic>\n \u00a0=\u00a054) and two matched comparison groups (1\u00a0:\u00a03); an alcohol comparison group (\n n<\/jats:italic>\n \u00a0=\u00a0162) and a community comparison group (\n n<\/jats:italic>\n \u00a0=\u00a0162).\n <\/jats:p>\n <\/jats:sec>\n \n Measurements<\/jats:title>\n The prevalence of acamprosate exposure was calculated per 100\u2009000 pregnancies. Three primary measures of maternal and neonatal health were used: maternal hospital admissions, birth weight and fetal alcohol syndrome (FAS).<\/jats:p>\n <\/jats:sec>\n \n Findings<\/jats:title>\n Exposure to acamprosate occurred in 7.7 [95% confidence interval (CI)\u00a0=\u00a06.0\u20139.7] in every 100\u2009000 pregnancies. Rates of hospital admissions during pregnancy and 42\u00a0days post\u2010partum in acamprosate\u2010treated women were not significantly different from women in the community comparison group [adjusted rate ratio (RR)\u00a0=\u00a00.85, 95% CI\u00a0=\u00a00.65\u20131.11], but were significantly lower compared with the alcohol comparison group (adjusted RR\u00a0=\u00a01.26, 95% CI\u00a0=\u00a01.00\u20131.60). Acamprosate\u2010exposed neonates were not significantly different from the alcohol comparison group or the community comparison group in terms of birth weight or proportion of small\u2010for\u2010gestational\u2010age neonates or incidence of congenital abnormalities (including FAS).<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n The prevalence of acamprosate use in pregnancy in New South Wales, Australia is low. Acamprosate exposure\n in utero<\/jats:italic>\n is not clearly associated with poor maternal or neonatal health outcomes.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/add.14429","type":"journal-article","created":{"date-parts":[[2018,8,28]],"date-time":"2018-08-28T05:49:35Z","timestamp":1535435375000},"page":"206-215","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Prevalence and safety of acamprosate use in pregnant alcohol\u2010dependent women in New South Wales, Australia"],"prefix":"10.1111","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0841-2216","authenticated-orcid":false,"given":"Erin","family":"Kelty","sequence":"first","affiliation":[{"name":"Centre for Health Services Research, School of Population and Global Health the University of Western Australia WA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duong","family":"Tran","sequence":"additional","affiliation":[{"name":"Centre for Big Data Research in Health University of New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina","family":"Lavin","sequence":"additional","affiliation":[{"name":"Centre for Health Services Research, School of Population and Global Health the University of Western Australia WA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David B.","family":"Preen","sequence":"additional","affiliation":[{"name":"Centre for Health Services Research, School of Population and Global Health the University of Western Australia WA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Hulse","sequence":"additional","affiliation":[{"name":"Division of Psychiatry, the School of Medicine the University of Western Australia WA Australia"},{"name":"School of Medical and Health Sciences Edith Cowan University Joondalup WA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alys","family":"Havard","sequence":"additional","affiliation":[{"name":"Centre for Big Data Research in Health University of New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,9,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alcohol.2008.04.003"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1980.tb05628.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.12939"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11065-011-9166-x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/GRF.0b013e31816fea3d"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/HRP.0000000000000070"},{"key":"e_1_2_8_8_1","first-page":"47","article-title":"Fetal alcohol syndrome: does alcohol withdrawal play a role?","volume":"22","author":"Thomas J. 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