{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T06:00:14Z","timestamp":1780984814088,"version":"3.54.1"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,11,13]],"date-time":"2018-11-13T00:00:00Z","timestamp":1542067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2018,11,13]],"date-time":"2018-11-13T00:00:00Z","timestamp":1542067200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100005240","name":"Administration for Children and Families","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005240","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>In general populations, prenatal food insecurity negatively affects maternal and infant health. Our aim was to estimate and test the association between prenatal food insecurity and neonatal abstinence syndrome (NAS) severity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design\/Setting<\/jats:title>\n                    <jats:p>Single\u2010site prospective cohort design. Women receiving opioid agonist treatment with methadone or buprenorphine were interviewed (including demographics and food insecurity) during the third trimester at the combined obstetric\/opioid use disorder treatment clinic at Boston Medical Center (BMC) in Boston, MA, USA, a large urban safety\u2010net hospital. During postnatal hospitalization, infants were assessed and treated per hospital NAS protocol. Maternal clinic and infant hospitalization data were abstracted from medical records.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>\n                      Women (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a075; aged \u2265\u00a018\u00a0years; fluent English; singleton pregnancy; intending to deliver at BMC and maintain parental custody) receiving care in the specialized clinic were study eligible (2013\u201315). Women who delivered infants &lt;\u00a036\u00a0weeks gestational age or required prolonged newborn intensive care unit stay were excluded from analyses.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Primary measurements<\/jats:title>\n                    <jats:p>Predictors: validated two\u2010question Hunger Vital Sign\u2122 food insecurity screener; outcomes: extent of NAS pharmacological treatment and length of hospital stay (LOS) for NAS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Findings<\/jats:title>\n                    <jats:p>\n                      Of the mother\u2013infant dyads, 61 (81%) infants were treated pharmacologically for NAS. Mean hospital LOS was 19.9 (standard deviation\u00a0=\u00a09.4) days. Maternal food insecurity (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a043, 57.3%) was associated with infant NAS pharmacological treatment in logistic regression analyses individually adjusted for prenatal: maternal depression [adjusted odds ratios (aOR)\u00a0=\u00a03.69 (95% confidence intervals (CI)\u00a0=\u00a01.02\u201313.43,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.05)] and methadone agonist treatment [aOR\u00a0=\u00a04.17 (95% CI\u00a0=\u00a01.05\u201316.50,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.04)]. Associations of food insecurity and LOS were inconclusive regardless of covariate control (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&gt;\u00a00.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Among women receiving opioid agonist treatment, prenatal food insecurity appears to be associated with increased risk for neonatal abstinence syndrome pharmacological treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/add.14458","type":"journal-article","created":{"date-parts":[[2018,11,13]],"date-time":"2018-11-13T09:05:49Z","timestamp":1542099949000},"page":"337-343","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Could prenatal food insecurity influence neonatal abstinence syndrome severity?"],"prefix":"10.1111","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4498-9570","authenticated-orcid":false,"given":"Ruth","family":"Rose\u2010Jacobs","sequence":"first","affiliation":[{"name":"Pediatrics Boston University School of Medicine and Boston Medical Center  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Trevino\u2010Talbot","sequence":"additional","affiliation":[{"name":"Pediatrics Boston Medical Center  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8714-5303","authenticated-orcid":false,"given":"Christine","family":"Lloyd\u2010Travaglini","sequence":"additional","affiliation":[{"name":"Biostatistics and Epidemiology Data Analytics Center Boston University School of Public Health  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1185-8331","authenticated-orcid":false,"given":"Howard J.","family":"Cabral","sequence":"additional","affiliation":[{"name":"Biostatistics Boston University School of Public Health  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5742-6921","authenticated-orcid":false,"given":"Martha","family":"Vibbert","sequence":"additional","affiliation":[{"name":"Pediatrics Boston University School of Medicine and Boston Medical Center  Mattapan MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9198-5295","authenticated-orcid":false,"given":"Kelley","family":"Saia","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Boston University School of Medicine and Boston Medical Center  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6307-6999","authenticated-orcid":false,"given":"Elisha M.","family":"Wachman","sequence":"additional","affiliation":[{"name":"Pediatrics Boston University School of Medicine and Boston Medical Center  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,11,13]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"Operational guidelines for the management of opioid dependence in the South\u2010East Asia Region","author":"World Health Organization (WHO)","year":"2008"},{"key":"e_1_2_8_3_1","volume-title":"Health and Social Responses to Drug Problems: a European Guide","author":"European Monitoring Centre for Drugs and Drug Addiction (EMCDDA)","year":"2017"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2016-2651"},{"key":"e_1_2_8_5_1","first-page":"e540","article-title":"The committee on drugs and the committee on fetus and newborn","volume":"129","author":"Hudak M. 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