{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T23:16:45Z","timestamp":1773011805189,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,11,25]],"date-time":"2018-11-25T00:00:00Z","timestamp":1543104000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100005564","name":"Gilead Sciences","doi-asserted-by":"publisher","award":["Nordic Fellowship grant 2015"],"award-info":[{"award-number":["Nordic Fellowship grant 2015"]}],"id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006356","name":"Syddansk Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006356","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and aims<\/jats:title><jats:p>The aims of this study were, in people in treatment for drug use in Funen, Denmark, to: (1) assess prevalence of hepatitis C virus (HCV) test uptake and prevalence of HCV; (2) identify predictors of test update and HCV infection; and (3) characterize changes between 1996 and 2015 in test uptake, HCV prevalence and drug use.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Cohort study linking the Danish National Registry on Drug Users in Treatment to the regional hepatitis test registry and the Danish Death Certificate Registry, thus combining longitudinal data on drug use with data on HCV testing and results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting and participants<\/jats:title><jats:p>People recorded as having received treatment for drug use between 1996 and 2015 (<jats:italic>n<\/jats:italic>\u00a0=\u00a05483) in Funen, Denmark. In the cohort, 24.8% were female, median age 23\u00a0years [interquartile range (IQR)\u00a0=\u00a020\u201332] at entry and 50% had self\u2010reported injecting or had received opiate substitution therapy (OST).<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements<\/jats:title><jats:p>The main outcomes were the test for HCV ever and latest HCV\u2010RNA being positive. The main predictors were for test and infection investigated; ever receiving OST, self\u2010reported injecting, age at entry and connection to treatment centre offering outreach hepatitis care.<\/jats:p><\/jats:sec><jats:sec><jats:title>Findings<\/jats:title><jats:p>HCV test uptake was 52% and prevalence of current HCV\u2010RNA+ was 21% in people alive at the end of follow\u2010up. Positive predictors of having undergone HCV testing were: receiving OST [odds ratio (OR)\u00a0=\u00a03.7; 95% confidence interval (CI)\u00a0=\u00a03.2\u20134.5], self\u2010reported injecting (OR\u00a0=\u00a02.3; 95% CI\u00a0=\u00a02.0\u20132.7), female gender (OR\u00a0=\u00a01.7; 95% CI\u00a0=\u00a01.4\u20131.9) and having been connected to centres with outreach hepatitis care (OR\u00a0=\u00a01.4; 95% CI\u00a0=\u00a01.2\u20131.7). In people alive, HCV\u2010RNA+ prevalence was 31% if ever on OST or self\u2010reported injecting. Among HCV\u2010infected people, 69% were in drug use treatment at end of follow\u2010up. For participants entering the cohort after 2010, only 5% reported opiates as main drug of use and 17% had experience of injecting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Among Danish people in treatment for drug use from 1996 to 2015, receiving opiate substitution therapy had the largest associating to being tested for hepatitis C virus. As opiate use is declining, adapting test strategies will be necessary.<\/jats:p><\/jats:sec>","DOI":"10.1111\/add.14479","type":"journal-article","created":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T21:42:04Z","timestamp":1540244524000},"page":"494-503","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Test uptake and hepatitis C prevalence in 5483 Danish people in drug use treatment from 1996 to 2015: a registry\u2010based cohort study"],"prefix":"10.1111","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2594-6500","authenticated-orcid":false,"given":"Anne","family":"\u00d8vrehus","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases Odense University Hospital  Odense C Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stine","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Odense University Hospital  Odense C Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janne Fuglsang","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Odense University Hospital  Odense C Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorte Kinggaard","family":"Holm","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Odense University Hospital  Odense C Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peer","family":"Christensen","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Odense University Hospital  Odense C Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,11,25]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"World Health Organization (WHO).Global health sector strategy on viral hepatitis 2016\u20132021. Geneva Switzerland: WHO;2016."},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0103345"},{"key":"e_1_2_7_4_1","series-title":"EMCDDA Insights 23","volume-title":"Hepatitis C Among Drug Users in Europe: Epidemiology, Treatment and Prevention","author":"European Monitoring Centre for Drugs and Drug Addiction (EMCDDA)","year":"2016"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61097-0"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(17)30375-3"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.07.012"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/add.14012"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2010.03118.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugpo.2012.02.002"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/pubmed\/fds018"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugpo.2015.07.010"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugpo.2017.07.002"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugpo.2017.05.019"},{"key":"e_1_2_7_15_1","unstructured":"Statistics Denmark\u2010www.statbank.dk.Table FOLK1C Province Funen age group 15\u201079 1. 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