{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T03:45:46Z","timestamp":1790653546206,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,3,10]],"date-time":"2019-03-10T00:00:00Z","timestamp":1552176000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>To compare individuals with comorbid life\u2010time post\u2010traumatic stress disorder (PTSD) and alcohol use disorders [AUD; i.e. no drug use disorders (DUD)] with those with comorbid PTSD and DUD on past\u2010year prevalence of these disorders, social functioning, life\u2010time psychiatric comorbidities, and treatment receipt. The comorbid groups were also compared with their single diagnosis counterparts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design and Setting<\/jats:title><jats:p>Cross\u2010sectional cohort study using data from the National Epidemiologic Survey of Alcohol and Related Conditions (NESARC\u2010III).<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>The total sample size was 36\u2009309. Six groups were established: PTSD\/AUD, PTSD\/DUD, AUD, DUD, PTSD, and neither PTSD nor AUD\/DUD. Life\u2010time prevalence of AUD among those with PTSD\/DUD was 80.2% and among those with DUD was 73.8%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements<\/jats:title><jats:p>The Alcohol Use Disorder and Associated Disabilities Interview Schedule\u2010DSM\u20105 version assessed life\u2010time and past\u2010year psychiatric disorders and treatment receipt. Demographics and social stability indicators were queried. Group characteristics were summarized using weighted means. Prevalences and estimates for adjusted differences in means and adjusted odds ratios (aORs) were derived from multiple linear regression and logistic regression models, respectively. Analyses were conducted in R and accounted for the NESARC\u2010III's complex survey design, clustering, and non\u2010response.<\/jats:p><\/jats:sec><jats:sec><jats:title>Findings<\/jats:title><jats:p>Compared with those with life\u2010time PTSD\/AUD, those with life\u2010time PTSD\/DUD were significantly less likely to have neither disorder in the past year (PTSD\/AUD =\u00a016.1%; PTSD\/DUD\u00a0=\u00a08.5%; aOR\u00a0=\u00a00.54), and were more likely to report worse social and psychiatric functioning, and to have received both addiction and mental health treatment (PTSD\/AUD\u00a0=\u00a018.4%; PTSD\/DUD\u00a0=\u00a043.2%; aOR\u00a0=\u00a03.88). Compared with their single disorder counterparts, those with PTSD\/DUD reported greater impairment than both groups, whereas the comorbid PTSD\/AUD group differed more from the AUD than the PTSD group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>People with comorbid PTSD and drug use disorder have greater social and psychiatric impairment and may require different types and intensity of intervention than people with comorbid post\u2010traumatic stress disorder and alcohol use disorder.<\/jats:p><\/jats:sec>","DOI":"10.1111\/add.14565","type":"journal-article","created":{"date-parts":[[2019,1,29]],"date-time":"2019-01-29T22:25:43Z","timestamp":1548800743000},"page":"983-993","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":81,"title":["Clinical presentations, social functioning, and treatment receipt among individuals with comorbid life\u2010time PTSD and alcohol use disorders versus drug use disorders: findings from NESARC\u2010III"],"prefix":"10.1111","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3333-9735","authenticated-orcid":false,"given":"Tracy L.","family":"Simpson","sequence":"first","affiliation":[{"name":"Center of Excellence in Substance Abuse and Treatment (CESATE) VA Puget Sound Health Care System  Seattle WA USA"},{"name":"Department of Psychiatry and Behavioral Sciences University of Washington  Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Rise","sequence":"additional","affiliation":[{"name":"Denver\u2010Seattle Center of Innovation for Veteran\u2010Centered Value\u2010Driven Care VA Puget Sound Health Care System  Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kendall C.","family":"Browne","sequence":"additional","affiliation":[{"name":"Center of Excellence in Substance Abuse and Treatment (CESATE) VA Puget Sound Health Care System  Seattle WA USA"},{"name":"Department of Psychiatry and Behavioral Sciences University of Washington  Seattle WA USA"},{"name":"Center of Excellence in Substance Abuse and Treatment (CESATE) Corporal Michael J. Crescenz VA Medical Center  Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keren","family":"Lehavot","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences University of Washington  Seattle WA USA"},{"name":"Denver\u2010Seattle Center of Innovation for Veteran\u2010Centered Value\u2010Driven Care VA Puget Sound Health Care System  Seattle WA USA"},{"name":"Department of Health Services University of Washington  Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debra","family":"Kaysen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences University of Washington  Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,3,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-012-0300-0"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2013.04.016"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsat.2011.02.012"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2015.09.007"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2017.07.012"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.2006.163.4.652"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2008.10.015"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2016.03.016"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00127-014-0855-7"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00127-016-1208-5"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addbeh.2013.08.026"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsat.2014.10.014"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addbeh.2013.06.001"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jts.21690"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.08m04545"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.15m10358"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2006.12.010"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v66n0602"},{"key":"e_1_2_7_20_1","first-page":"148","article-title":"Diagnosing co\u2010morbid drug use in patients with alcohol use disorders","volume":"31","author":"Arnaout B.","year":"2008","journal-title":"Alcohol Res Health"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addbeh.2015.06.041"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2005.03.009"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)61611-6"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2018.03.006"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2018.01.035"},{"key":"e_1_2_7_26_1","unstructured":"Center for Behavioral Health Statistics and Quality.\u2009Behavioral Health Trends in the United States: Results from the 2014 National Survey on Drug Use and Health. Available at:https:\/\/www.samhsa.gov\/data\/report\/behavioral\u2010health\u2010trends\u2010united\u2010states\u2010results\u20102014\u2010national\u2010survey\u2010drug\u2010use\u2010and\u2010health\u2010nsduh(accessed 13\u00a0January 2019)."},{"key":"e_1_2_7_27_1","unstructured":"American Community Survey 2012. Suitland MD;2013."},{"key":"e_1_2_7_28_1","first-page":"1","volume-title":"Source and Accuracy Statement: National Epidemiologic Survey on Alcohol and Related Conditions\u2010III (NESCAR\u2010III)","author":"Grant B. F.","year":"2014"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2015.2132"},{"key":"e_1_2_7_30_1","volume-title":"The Alcohol Use Disorder and Associated Disabilities Interview Schedule","author":"Grant B. F.","year":"2011"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2017.09.008"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2015.0584"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2014.11.026"},{"key":"e_1_2_7_34_1","volume-title":"R: A Language and Environment for Statistical Computing","author":"R Development Core Team","year":"2017"},{"key":"e_1_2_7_35_1","unstructured":"AquinoJ.\u2009Descr: Descriptive Statistics. R package version 1.1.4;2018. Available at:https:\/\/CRAN.R-project.org\/package=descr(accessed January 3 2018) (Archived athttp:\/\/www.webcitation.org\/76ByDJcRZ)."},{"key":"e_1_2_7_36_1","unstructured":"LumleyT.\u2009Survey: Analysis of Complex Survey Samples. R package version 3.32;2017. Available at:http:\/\/r\u2010survey.r\u2010forge.r\u2010project.org\/survey\/(accessed January 3 2018) (Archived athttp:\/\/www.webcitation.org\/76ByX7IUw)"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v009.i08"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1995.tb02031.x"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291709990328"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1037\/prj0000135"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cobeha.2016.11.014"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addbeh.2017.08.019"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40479-014-0024-3"}],"container-title":["Addiction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fadd.14565","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/add.14565","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/add.14565","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/add.14565","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T09:00:16Z","timestamp":1694336416000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/add.14565"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,10]]},"references-count":42,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["10.1111\/add.14565"],"URL":"https:\/\/doi.org\/10.1111\/add.14565","archive":["Portico"],"relation":{},"ISSN":["0965-2140","1360-0443"],"issn-type":[{"value":"0965-2140","type":"print"},{"value":"1360-0443","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,10]]},"assertion":[{"value":"2018-09-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}