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The objective of this investigation was to examine injecting cessation episodes of 1\u20133\u2010month duration as predictors of hepatitis C virus (HCV) acquisition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Montr\u00e9al, Canada.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>A total of 372 HCV\u2010uninfected (HCV RNA\u2010negative, HCV antibody\u2010positive or \u2010negative) PWID (mean age\u00a0=\u00a039.3\u00a0years, 82% male, 45% HCV antibody\u2010positive) enrolled between March 2011 and June 2016.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements<\/jats:title>\n                    <jats:p>At 3\u2010month intervals, participants completed an interviewer\u2010administered questionnaire and were tested for HCV particles (HCV RNA). At each visit, participants indicated whether they injected in each of the past 3\u00a0months (defined as three consecutive 30\u2010day periods). Injecting cessation patterns were evaluated on a categorical scale: persistent injecting (no injecting cessation in the past 3\u00a0months), sporadic injecting cessation (injecting cessation in 1 of 3 or 2 of 3\u00a0months) and short injecting cessation (injecting cessation in 3 of 3\u00a0months). Their association with HCV infection risk was examined using Cox regression analyses with time\u2010dependent covariates, including age, gender, incarceration, opioid agonist treatment and other addiction treatments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Findings<\/jats:title>\n                    <jats:p>At baseline, 61, 26 and 13% of participants reported persistent injecting, sporadic injecting cessation and short injecting cessation, respectively. HCV incidence was 7.5 per 100 person\u2010years [95%\u00a0confidence interval (CI)\u00a0=\u00a05.9\u20139.5; 916 person\u2010years of follow\u2010up]. In adjusted Cox models, sporadic injecting cessation and short injecting cessation were associated with lower risks of incident HCV infection compared to persistent injecting (adjusted hazard ratios\u00a0=\u00a00.56, 95% CI\u00a0=\u00a00.30\u20131.04 and 0.24, 95% CI\u00a0=\u00a00.09\u20130.61), respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Short and sporadic injecting cessation episodes were common among a cohort of people who inject drugs in Montr\u00e9al, Canada. Injecting cessation episodes appear to be protective against hepatitis C virus acquisition, particularly when maintained for at least 3\u00a0months.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/add.14632","type":"journal-article","created":{"date-parts":[[2019,4,7]],"date-time":"2019-04-07T22:24:52Z","timestamp":1554675892000},"page":"1495-1503","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Short and sporadic injecting cessation episodes as predictors of incident hepatitis C virus infection: findings from a cohort study of people who inject drugs in Montr\u00e9al, Canada"],"prefix":"10.1111","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3933-2996","authenticated-orcid":false,"given":"Emmanuel","family":"Fortier","sequence":"first","affiliation":[{"name":"CHUM Research Centre Centre hospitalier de l'Universit\u00e9 de Montr\u00e9al  Montr\u00e9al QC Canada"},{"name":"Department of 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