{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T06:05:12Z","timestamp":1780985112986,"version":"3.54.1"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,11,25]],"date-time":"2019-11-25T00:00:00Z","timestamp":1574640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2019,11,25]],"date-time":"2019-11-25T00:00:00Z","timestamp":1574640000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100006602","name":"Air Force Research Laboratory","doi-asserted-by":"publisher","award":["FA8650\u201018\u20102\u20106833"],"award-info":[{"award-number":["FA8650\u201018\u20102\u20106833"]}],"id":[{"id":"10.13039\/100006602","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["K23 GM110516"],"award-info":[{"award-number":["K23 GM110516"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["CTSI UL1 TR001082"],"award-info":[{"award-number":["CTSI UL1 TR001082"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background and aims<\/jats:title>\n                    <jats:p>The Psychoactive Surveillance Consortium and Analysis Network (PSCAN) is a national network of academic emergency departments (ED), analytical toxicologists and pharmacologists that collects clinical data paired with biological samples to identify and improve treatments of medical conditions arising from use of new psychoactive substances (NPS). The aim of this study was to gather clinical data with paired drug identification from NPS users who presented to EDs within PSCAN during its first year (2016\u201317).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Observational study involving patient records and biological samples.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Seven academic emergency medical centers across the United States.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>\n                      ED patients (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0127) &gt;\u00a08\u00a0years of age with possible NPS use who were identified and enrolled in PSCAN by clinical providers or research personnel.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements<\/jats:title>\n                    <jats:p>Clinical signs, symptoms and treatments were abstracted from the patients' health records. Biological samples were collected from leftover urine, serum and whole blood. Biological and drug samples, when available, were tested for drugs and drug metabolites via liquid chromatography\u2013quadrupole time\u2010of\u2010flight mass spectrometry (LC\u2010QTOF\/MS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Findings<\/jats:title>\n                    <jats:p>\n                      Patients in whom synthetic opioids were detected (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a09) showed higher rates of intubation (four of nine), impaired mental status (four of nine) and respiratory acidosis (five of nine) compared with the rest of the cohort (nine of 118,\n                      <jats:italic>P<\/jats:italic>\n                      \u2010value &lt;\u00a00.05). Patients in whom synthetic cannabinoid (SC) were found (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a027) had lower median diastolic blood pressures (70.5\u00a0versus 77\u00a0mmHg,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.046) compared with the rest of the cohort. In 64 cases of single drug ingestion, benzodiazepines were administered in 25 cases and considered effective by the treating physician in 21 (84%) cases.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>During its first year of operation, the Psychoactive Surveillance Consortium and Analysis Network captured clinical data on new classes of drugs paired with biological samples over a large geographical area in the United States. Synthetic cannabinoids were the most common new psychoactive drug identified. Synthetic opioids were associated with a high rate of intubation and respiratory acidosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/add.14808","type":"journal-article","created":{"date-parts":[[2019,11,25]],"date-time":"2019-11-25T21:19:01Z","timestamp":1574716741000},"page":"270-278","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["The Psychoactive Surveillance Consortium and Analysis Network (PSCAN): the first year"],"prefix":"10.1111","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6210-8418","authenticated-orcid":false,"given":"Andrew A.","family":"Monte","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine University of Colorado School of Medicine  Aurora CO USA"},{"name":"Denver Health and Hospital Authority Rocky Mountain Poison and Drug Center  Denver CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Hopkinson","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine University of Colorado School of Medicine  Aurora CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Saben","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine University of Colorado School of Medicine  Aurora CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelby K.","family":"Shelton","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine University of Colorado School of Medicine  Aurora CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Thornton","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine University of Kansas  Kansas City KS USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Schneir","sequence":"additional","affiliation":[{"name":"University of California San Diego Health System Division of Medical Toxicology Department of Emergency Medicine San Diego  CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Pomerleau","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Emory University  Atlanta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert G.","family":"Hendrickson","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Oregon Health and Science University  Portland OR USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann M.","family":"Arens","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Hennepin Healthcare  Minneapolis MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon B.","family":"Cole","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Hennepin Healthcare  Minneapolis MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Chenoweth","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine University of California, Davis  Sacramento CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Spencer","family":"Martin","sequence":"additional","affiliation":[{"name":"Clinical Toxicology and Environmental Biomonitoring Lab University of California San Francisco  San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Adams","sequence":"additional","affiliation":[{"name":"Clinical Toxicology and Environmental Biomonitoring Lab University of California San Francisco  San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel D.","family":"Banister","sequence":"additional","affiliation":[{"name":"The School of Chemistry The University of Sydney  Sydney NSW Australia"},{"name":"The Lambert Initiative for Cannabinoid Therapeutics, The Brain and Mind Centre The University of Sydney  Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy R.","family":"Gerona","sequence":"additional","affiliation":[{"name":"Clinical Toxicology and Environmental Biomonitoring Lab University of California San Francisco  San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,11,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.2174\/13816128113199990622"},{"key":"e_1_2_7_3_1","volume-title":"Monitoring the Future National Results on Drug Use: 2012 Overview, Key Findings on Adolescent Drug Use","author":"Johnston 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