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This study aimed to summarize the evidence relating illicit opioid use with poor respiratory health.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A systematic review of the literature on the association between illicit opioid use and respiratory health was undertaken in accordance with Preferred Reporting Items for Systematic Reviews and Meta\u2010Analyses (PRISMA) guidance (PROSPERO ID\u00a0=\u00a0CRD42017059953). Electronic searches of MEDLINE, Embase, PsycINFO, CINAHL and the Cochrane Library databases were undertaken (English language, published January 1980\u2013November 2018). All study designs excluding case studies were considered. Studies were undertaken in community and hospital settings in the United States (<jats:italic>n<\/jats:italic>\u00a0=\u00a023), United Kingdom (<jats:italic>n<\/jats:italic>\u00a0=\u00a07), Australia (<jats:italic>n<\/jats:italic>\u00a0=\u00a07), the Netherlands (<jats:italic>n<\/jats:italic>\u00a0=\u00a02), Canada (<jats:italic>n<\/jats:italic>\u00a0=\u00a02), Ireland (<jats:italic>n<\/jats:italic>\u00a0=\u00a01), Spain (<jats:italic>n<\/jats:italic>\u00a0=\u00a01) and Iran (<jats:italic>n<\/jats:italic>\u00a0=\u00a01). Measurements of respiratory disease, including asthma and chronic obstructive pulmonary disease (COPD) and related symptoms were extracted. Data on respiratory\u2010related deaths and hospital admissions were also extracted. Meta\u2010analysis of prevalence data was undertaken using a random effects meta\u2010analysis model with parameters estimated using Markov chain Monte Carlo simulation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Meta\u2010analyses estimated prevalence of asthma in people who inject illicit opioids as 8.5% [95% predictive interval (PrI)\u00a0=\u00a00.2%, 74.0%] and as 20.2% (95% PrI\u00a0=\u00a04.2%, 59.2%) in people who inhale illicit opioids. Prevalence of COPD in people who inject illicit opioids was estimated as 2.7% (95% PrI\u00a0=\u00a00.0%, 50.4%) and as 17.9% (95% PrI\u00a0=\u00a00.6%, 89.5%) in people who inhale illicit opioids. There was evidence of moderate to extreme heterogeneity across studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There is evidence of increased burden of respiratory diseases in people who use illicit opioids. Due to the heterogeneity of study design and samples, it is difficult to gain accurate estimates of the prevalence of respiratory disease in this population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/add.14870","type":"journal-article","created":{"date-parts":[[2019,11,6]],"date-time":"2019-11-06T11:20:06Z","timestamp":1573039206000},"page":"832-849","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Prevalence of respiratory conditions among people who use illicit opioids: a systematic review"],"prefix":"10.1111","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2159-7232","authenticated-orcid":false,"given":"Joe","family":"Hulin","sequence":"first","affiliation":[{"name":"School of Health and Related Research (ScHARR) The University of Sheffield  Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8020-0066","authenticated-orcid":false,"given":"Arjuna","family":"Brodie","sequence":"additional","affiliation":[{"name":"School of Health and Related Research (ScHARR) The University of Sheffield  Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9867-7209","authenticated-orcid":false,"given":"John","family":"Stevens","sequence":"additional","affiliation":[{"name":"School of Health and Related Research (ScHARR) The University of Sheffield  Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4790-0095","authenticated-orcid":false,"given":"Caroline","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Academic Unit of Primary Medical Care The University of Sheffield  Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,1,13]]},"reference":[{"key":"e_1_2_8_3_1","unstructured":"Public Health England (PHE).Adult Substance Misuse Statistics from the National Drug Treatment Monitoring System (NDTMS). 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