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Total costs, including smoking cessation, health\u2010care and social services costs and quality\u2010adjusted life years (QALYs), derived from the five\u2010level EuroQol 5\u2010dimension (EQ\u20105D\u20105\u00a0L), collected from a randomized controlled trial, were used as outcome measures. The bootstrap technique was employed to assess the uncertainty.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Sixteen primary care and 21 secondary care mental health sites in England.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>Adult smokers with bipolar affective disorder, schizoaffective disorder or schizophrenia and related illnesses (<jats:italic>n<\/jats:italic>\u00a0=\u00a0526).<\/jats:p><\/jats:sec><jats:sec><jats:title>Intervention and comparator<\/jats:title><jats:p>A bespoke smoking cessation (BSC) package for people with severe mental illness offered up to 12 individual sessions with a mental health smoking cessation practitioner versus usual care (UC). Of the participants who were randomized, 261 were in UC group and 265 were in BSC group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements<\/jats:title><jats:p>BSC intervention cost was estimated from the treatment log. Costs of UC, health\u2010care and social services and EQ\u20105D\u20105\u00a0L were collected at baseline, 6\u2010 and 12\u2010month follow\u2010ups. Incremental costs and incremental QLAYs were estimated using regression adjusting for respective baseline values and other baseline covariates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Findings<\/jats:title><jats:p>The mean total cost in the BSC group was \u00a3270 [95% confidence interval (CI)\u00a0=\u00a0\u2013\u00a31690 to \u00a31424] lower than in the UC group, while the mean QALYs were 0.013 (95% CI\u00a0=\u00a0\u20130.008 to 0.045) higher, leading to BSC dominating UC (76% probability of cost\u2010effective at \u00a320\u2009000\/QALY).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A bespoke smoking cessation package for people with severe mental illness is likely to be cost\u2010effective over 12\u00a0months compared with usual care provided by the UK's National Health Service and personal social services.<\/jats:p><\/jats:sec>","DOI":"10.1111\/add.15086","type":"journal-article","created":{"date-parts":[[2020,4,22]],"date-time":"2020-04-22T07:15:38Z","timestamp":1587539738000},"page":"2113-2122","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Cost\u2010effectiveness of a specialist smoking cessation package compared with standard smoking cessation services for people with severe mental illness in England: a trial\u2010based economic evaluation from the SCIMITAR+ study"],"prefix":"10.1111","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1496-7450","authenticated-orcid":false,"given":"Jinshuo","family":"Li","sequence":"first","affiliation":[{"name":"Mental Health and Addictions Research Group (MHARG), Department of Health Sciences University of York York UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0547-462X","authenticated-orcid":false,"given":"Caroline","family":"Fairhurst","sequence":"additional","affiliation":[{"name":"York Trials Unit, Department of Health Sciences University of York York UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9377-1968","authenticated-orcid":false,"given":"Emily","family":"Peckham","sequence":"additional","affiliation":[{"name":"Mental Health and Addictions Research Group (MHARG), Department of Health Sciences University of York York UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6059-2111","authenticated-orcid":false,"given":"Della","family":"Bailey","sequence":"additional","affiliation":[{"name":"Mental Health and Addictions Research Group (MHARG), Department of Health Sciences University of York York UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0512-4339","authenticated-orcid":false,"given":"Catherine","family":"Arundel","sequence":"additional","affiliation":[{"name":"York Trials Unit, Department of Health Sciences University of York York UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0415-3536","authenticated-orcid":false,"given":"Catherine","family":"Hewitt","sequence":"additional","affiliation":[{"name":"York Trials Unit, Department of Health Sciences University of York York UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3529-5737","authenticated-orcid":false,"given":"Paul","family":"Heron","sequence":"additional","affiliation":[{"name":"Mental Health and Addictions Research Group (MHARG), Department of Health Sciences University of York York UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6658-6815","authenticated-orcid":false,"given":"Suzanne","family":"Crosland","sequence":"additional","affiliation":[{"name":"Mental Health and Addictions Research Group (MHARG), Department of Health Sciences University of York York UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0165-1150","authenticated-orcid":false,"given":"Steve","family":"Parrott","sequence":"additional","affiliation":[{"name":"Mental Health and Addictions Research Group (MHARG), Department of Health Sciences University of York York UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8236-6983","authenticated-orcid":false,"given":"Simon","family":"Gilbody","sequence":"additional","affiliation":[{"name":"Mental Health and Addictions Research Group (MHARG), Department of Health Sciences University of York York UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"SCIMITAR+ collaborative","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,6,3]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"Public Health England.Public Health Profiles.2020. 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