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To assess the factors contributing to the deaths, we compared individuals with and without previous substance use treatment and opioid use\u2010related diagnoses with regard to previous opioid agonist treatment (OAT), psychiatric care and previous pain medication. To assess the circumstances of deaths, we analyzed the presence of other drugs and other factors at time of death.<\/jats:p><\/jats:sec><jats:sec><jats:title>Findings<\/jats:title><jats:p>We identified 269 methadone\u2010related deaths, and the rate increased during the study period. Seventy\u2010two (27%) cases had not previously received substance use treatment, 112 (42%) had received treatment but had no opioid use\u2010related diagnosis and 85 (32%) had received treatment and had an opioid use\u2010related diagnosis. In total, only 10 individuals had been prescribed methadone during the year before death. Prescriptions of benzodiazepines (60%), antidepressants (62%) and opioids for pain (22%) the year before death were common. Most deaths occurred during sleep with a time lag from ingestion of methadone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Prescription opioid\u2010 and methadone\u2010related deaths increased in the group aged 15\u201329\u00a0years in Sweden between 2006 and 2015. Exposure to non\u2010prescribed methadone and prescribed benzodiazepines, antidepressants and opioids for pain appears to be common in drug\u2010related deaths in youth and young adults in Sweden.<\/jats:p><\/jats:sec>","DOI":"10.1111\/add.15152","type":"journal-article","created":{"date-parts":[[2020,6,13]],"date-time":"2020-06-13T07:15:02Z","timestamp":1592032502000},"page":"319-327","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Methadone\u2010related deaths among youth and young adults in Sweden 2006\u201315"],"prefix":"10.1111","volume":"116","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7736-4123","authenticated-orcid":false,"given":"Anna","family":"Fugelstad","sequence":"first","affiliation":[{"name":"Department of Clinical Neuroscience Karolinska Institute  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9243-548X","authenticated-orcid":false,"given":"Sven","family":"Bremberg","sequence":"additional","affiliation":[{"name":"Department of Public Health Karolinska Institute  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6422-284X","authenticated-orcid":false,"given":"Peter","family":"Hjelmstr\u00f6m","sequence":"additional","affiliation":[{"name":"Camurus AB,\u00a0Ideon Science Park  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2962-2466","authenticated-orcid":false,"given":"Ingmar","family":"Thiblin","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, Section for Forensic Medicine Uppsala University  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1965.03090080008002"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-018-0094-5"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1990.tb03057.x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1360-0443.1995.90571112.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1997.tb10147.x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2006.01714.x"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2019.04.022"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2012.11.010"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000446429"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00414-016-1358-8"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.14019"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4637.2011.01134.x"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-842X.2002.tb00185.x"},{"key":"e_1_2_10_15_1","first-page":"352","article-title":"Methadone\u2010related fatalities: review in the Ghent district between 1978\u20132008","volume":"67","author":"Van Den Broecke S. 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