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The control group did not receive any intervention to prevent alcohol and drug use.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements<\/jats:title><jats:p>The primary outcome measured was prevalence of binge drinking (five or more doses of alcohol in an occasion) within the past month. Secondary outcomes were prevalence of initiation and use of alcohol, tobacco, inhalants, marijuana and cocaine within the past month.<\/jats:p><\/jats:sec><jats:sec><jats:title>Findings<\/jats:title><jats:p>A statistically significant difference was not found in the prevalence of binge drinking within the past month between intervention and control groups [odds ratio (OR)\u00a0=\u00a00.934; 95% confidence interval (CI)\u00a0=\u00a00.761\u20131.146]. However, students who were exposed to the program were less likely to initiate alcohol use than those in the control group (OR\u00a0=\u00a00.782; 95% CI\u00a0=\u00a00.636\u20130.961). The Bayes factor for reduction in binge drinking was 0.01, providing evidence in favor of the null hypothesis for this variable.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The drug prevention program #Tamojunto 2.0 reduced alcohol initiation, but appeared not to reduce past\u2010month binge drinking among 8th grade students in Brazil.<\/jats:p><\/jats:sec>","DOI":"10.1111\/add.15358","type":"journal-article","created":{"date-parts":[[2020,11,27]],"date-time":"2020-11-27T17:38:44Z","timestamp":1606498724000},"page":"1580-1592","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["A cluster randomized controlled trial evaluating the effectiveness of the school\u2010based drug prevention program #Tamojunto2.0"],"prefix":"10.1111","volume":"116","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7427-7956","authenticated-orcid":false,"given":"Zila M.","family":"Sanchez","sequence":"first","affiliation":[{"name":"Department of Preventive Medicine, Section of Epidemiology and Biostatistics Universidade Federal de S\u00e3o Paulo  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4408-2952","authenticated-orcid":false,"given":"Juliana Y.","family":"Valente","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, Section of Epidemiology and Biostatistics Universidade Federal de S\u00e3o Paulo  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4431-4787","authenticated-orcid":false,"given":"Patricia P.","family":"Galv\u00e3o","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, Section of Epidemiology and Biostatistics Universidade Federal de S\u00e3o Paulo  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3016-9619","authenticated-orcid":false,"given":"Fabiane A.","family":"Gubert","sequence":"additional","affiliation":[{"name":"Escola de Enfermagem Universidade Federal do Cear\u00e1  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2061-1832","authenticated-orcid":false,"given":"M\u00e1rcia H. 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