{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T14:49:41Z","timestamp":1790952581499,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,2,9]],"date-time":"2021-02-09T00:00:00Z","timestamp":1612828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["125864"],"award-info":[{"award-number":["125864"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>Cocaine use disorder (CUD) is a significant public health concern for which no efficacious pharmacological interventions are available. Cannabidiol (CBD) has attracted considerable interest as a promising treatment for addiction. This study tested CBD efficacy for reducing craving and preventing relapse in people with CUD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Single\u2010site double\u2010blind randomized controlled superiority trial comparing CBD with placebo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting and Participants<\/jats:title><jats:p>Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al, Canada. Seventy\u2010eight adults (14 women) with moderate to severe CUD participated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Intervention<\/jats:title><jats:p>Participants were randomly assigned (1\u00a0:\u00a01) by stratified blocks to daily 800\u00a0mg CBD (<jats:italic>n<\/jats:italic>\u00a0=\u00a040) or placebo (<jats:italic>n<\/jats:italic>\u00a0=\u00a038). They first underwent an inpatient detoxification phase lasting 10\u00a0days. Those who completed this phase entered a 12\u2010week outpatient follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements<\/jats:title><jats:p>Primary outcomes were drug\u2013cue\u2010induced craving during detoxication and time\u2010to\u2010cocaine relapse during subsequent outpatient treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Findings<\/jats:title><jats:p>During drug\u2013cue exposure, craving scores [mean \u00b1 standard deviation (SD)] increased from baseline by 4.69 (2.89) versus 3.21 (2.78) points, respectively, in CBD (<jats:italic>n<\/jats:italic>\u00a0=\u00a036) and placebo (<jats:italic>n<\/jats:italic>\u00a0=\u00a028) participants [confidence interval (CI)\u00a0=\u00a0\u22120.33 to 3.04; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.069; Bayes factor\u00a0=\u00a00.498]. All but three participants relapsed to cocaine by week 12 with similar risk for CBD (<jats:italic>n<\/jats:italic>\u00a0=\u00a034) and placebo (<jats:italic>n<\/jats:italic>\u00a0=\u00a027) participants (hazard ratio\u00a0=\u00a01.20, CI\u00a0=\u00a00.65\u20132.20, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.51; Bayes factor\u00a0=\u00a00.152). CBD treatment was well tolerated and associated mainly with diarrhoea.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>CBD did not reduce cocaine craving or relapse among people being treated for CUD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/add.15417","type":"journal-article","created":{"date-parts":[[2021,1,19]],"date-time":"2021-01-19T18:05:45Z","timestamp":1611079545000},"page":"2431-2442","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Cannabidiol as a treatment for craving and relapse in individuals with cocaine use disorder: a randomized placebo\u2010controlled trial"],"prefix":"10.1111","volume":"116","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8516-2620","authenticated-orcid":false,"given":"Violaine","family":"Mongeau\u2010P\u00e9russe","sequence":"first","affiliation":[{"name":"Research Center Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al (CRCHUM)  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