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Anxiety sensitivity may underlie both phenomena, such that people with high anxiety sensitivity react to interoceptive distress by avoidance. This study aimed to test the efficacy of an exercise program that induced interoceptive distress and thereby created tolerance to this distress in a safe environment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design, Setting and Participants<\/jats:title>\n                    <jats:p>\n                      Randomized clinical trial at four YMCA branches in Austin, Texas, USA. Participants [\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0150; 130 (86.7%) white; 101 (67.3%) female; mean\n                      <jats:sub>age<\/jats:sub>\n                      \u00a0=\u00a038.6, standard deviation (SD)\n                      <jats:sub>age<\/jats:sub>\n                      \u00a0=\u00a010.4] were adult, daily smokers with high anxiety sensitivity motivated to quit smoking, who reported no regular moderate\u2010intensity exercise.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interventions<\/jats:title>\n                    <jats:p>Participants were assigned a YMCA personal trainer who guided them through a 15\u2010week intervention aerobic exercise program. Participants assigned to the personalized intervention trained at 60\u201385% of their heart rate reserve (HRR), whereas participants assigned to the control intervention trained at 20\u201340% of their HRR. Participants in both groups received standard behavioral support and nicotine replacement therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements<\/jats:title>\n                    <jats:p>The primary outcome was biologically verified 7\u2010day point prevalence abstinence (PPA) at 6\u2010month follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Findings<\/jats:title>\n                    <jats:p>\n                      Sixty\u2010one per cent of participants were available at the 6\u2010month follow\u2010up. PPA at 6\u00a0months was higher in the personalized intervention than the control intervention [27.6 versus 14.8%; odds ratio (OR)\u00a0=\u00a02.20, 95% confidence interval (CI)\u00a0=\u00a01.28, 3.80,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.005], assuming missing at random. Anxiety sensitivity declined in both groups with no evidence that this differed between groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>An exercise program of high intensity increased abstinence from smoking in people with high anxiety sensitivity, but may not have done so by reducing anxiety sensitivity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/add.15586","type":"journal-article","created":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T09:07:53Z","timestamp":1621933673000},"page":"3188-3197","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Community\u2010based smoking cessation treatment for adults with high anxiety sensitivity: a randomized clinical trial"],"prefix":"10.1111","volume":"116","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1633-9693","authenticated-orcid":false,"given":"Jasper A. 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