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Self\u2010reported marijuana use frequency was calculated based on past\u2010month\u00a0days of use multiplied by number of daily uses. Maternal urine and sera were tested for presence (&gt;5\u00a0ng\/mL) of 11\u2010nor\u20109\u2010carboxy\u2010delta\u20109\u2010tetrahydrocannabinol (THC\u2010COOH). Liquid chromatography tandem mass spectrometry quantified THC\u2010COOH in umbilical cord homogenate (ng\/g). Last marijuana use by any measure was recorded to evaluate the time frame over which THC\u2010COOH remains detectable (&gt;0.10\u00a0ng\/g) in cord.<\/jats:p><\/jats:sec><jats:sec><jats:title>Findings<\/jats:title><jats:p>From December 2017 through May 2019, 51 pregnant women enrolled, and 46 were included in analyses (2 withdrew and 3 had a spontaneous abortion). The majority were normal weight, White or Black race, and insured by Medicaid. At the time of enrollment between 7 to 15\u00a0weeks\u2019 gestation, 87% had ongoing use by self\u2010report, or positive urine or serum. The majority (33 [66%]) stopped using before delivery. Sera and urine results were strongly correlated with self\u2010reported use frequency (Spearman correlation coefficient [r] range 0.70\u20130.87 across visits, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), and with each other. There was only one positive cord result when use stopped before 22\u00a0weeks. Frequency of self\u2010reported marijuana use at delivery had strong correlation with quantified cord THC\u2010COOH (r\u00a0=\u00a00.80, 95% CI = 0.62\u20130.89).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Quantified umbilical cord THC\u2010COOH appears to strongly correlate with frequency of maternal marijuana use in the last month of pregnancy. Earlier use can be measured by either quantitative urine or serum assay.<\/jats:p><\/jats:sec>","DOI":"10.1111\/add.15606","type":"journal-article","created":{"date-parts":[[2021,6,18]],"date-time":"2021-06-18T04:35:10Z","timestamp":1623990910000},"page":"172-181","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Quantification of prenatal marijuana use: evaluation of the correlation between self\u2010report, serum, urine and umbilical cord assays among women delivering at two urban Colorado hospitals"],"prefix":"10.1111","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8161-2353","authenticated-orcid":false,"given":"Torri D.","family":"Metz","sequence":"first","affiliation":[{"name":"University of Utah Health  Salt Lake City UT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gwendolyn A.","family":"McMillin","sequence":"additional","affiliation":[{"name":"University of Utah Health  Salt Lake City UT USA"},{"name":"ARUP Laboratories  Salt Lake City UT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert M.","family":"Silver","sequence":"additional","affiliation":[{"name":"University of Utah Health  Salt Lake City UT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda A.","family":"Allshouse","sequence":"additional","affiliation":[{"name":"University of Utah Health  Salt Lake City UT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kennon","family":"Heard","sequence":"additional","affiliation":[{"name":"University of Colorado School of Medicine  Aurora CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Triniti L.","family":"Jensen","sequence":"additional","affiliation":[{"name":"ARUP Laboratories  Salt Lake City UT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica M.","family":"Wymore","sequence":"additional","affiliation":[{"name":"Children's Hospital Colorado  Aurora CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine","family":"Stickrath","sequence":"additional","affiliation":[{"name":"University of Colorado School of Medicine  Aurora CO USA"},{"name":"Denver Health and Hospital Authority  Denver CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Conageski","sequence":"additional","affiliation":[{"name":"University of Colorado School of Medicine  Aurora CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory L.","family":"Kinney","sequence":"additional","affiliation":[{"name":"University of Colorado Denver  Aurora CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8862-8078","authenticated-orcid":false,"given":"Ingrid A.","family":"Binswanger","sequence":"additional","affiliation":[{"name":"University of Colorado School of Medicine  Aurora CO USA"},{"name":"Kaiser Permanente Colorado Institute for Health Research  Aurora CO USA"},{"name":"Colorado Permanente Medical Group  Denver CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.12626"},{"key":"e_1_2_8_3_1","first-page":"115","article-title":"Effects of marijuana on pregnancy and fetal development in the human","volume":"44","author":"Tennes K.","year":"1984","journal-title":"NIDA Res Monogr"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2017.08.015"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.17383"},{"key":"e_1_2_8_6_1","unstructured":"Committee on the Health Effects of Marijuana: An Evidence Review and Research Agenda; Board on Population Health and Public Health Practice; Health and Medicine Division; National Academies of Sciences.The Health Effects of Cannabis and Cannabinoids: The Current State of Evidence and Recommendations for Research.http:\/\/www.nap.edu\/246252017"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(95)90078-0"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/25.5.289"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7211416"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/bkt052"},{"key":"e_1_2_8_11_1","article-title":"Committee opinion no. 700. 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