{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T14:11:00Z","timestamp":1787148660446,"version":"build-2736575974"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T00:00:00Z","timestamp":1629072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and aims<\/jats:title><jats:p>Pharmacy administration and dispensing of methadone for methadone maintenance treatment (MMT) can expand treatment access for opioid use disorder (OUD). This study investigated the feasibility and acceptability of a novel model permitting an opioid treatment program (OTP) physician to prescribe methadone for OUD treatment through collaboration with a partnered pharmacy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Non\u2010randomized, single\u2010arm, open\u2010label feasibility trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>One OTP and one community pharmacy in the United States.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>One OTP physician, two pharmacists and 20 MMT patients receiving between six and 13 take\u2010home methadone doses at 5\u2013160\u00a0mg\/day.<\/jats:p><\/jats:sec><jats:sec><jats:title>Intervention<\/jats:title><jats:p>Patients\u2019 methadone administration and dispensing of take\u2010home doses was transferred from the OTP to the pharmacy for 3\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements<\/jats:title><jats:p>Primary outcome was medication adherence. Secondary outcomes were recruitment, treatment retention, substance use, counseling attendance at the OTP, pharmacist prescription drug monitoring program (PDMP) use, safety and satisfaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Findings<\/jats:title><jats:p>Of 29 patients eligible at pre\u2010screen, 20 patients (69%) enrolled into the study. Recruitment occurred from 6\u00a0August 2020 to 10 October 2020. Treatment retention rate at month 3 was 80% (16 of 20). Two participants returned early to the OTP because of a work\/schedule change, one due to pregnancy and one following a non\u2010study\u2010related hospitalization. Medication adherence among 16 patients who were retained was 100%. Intervention fidelity was 100%. All participants attended random call\u2010back visits. None showed evidence of tampering\/diversion of methadone. Pharmacists checked the PDMP at all visits. All participants attended psychosocial counseling as planned. There were no positive urine screens for illicit opioid use and no study\u2010related adverse events. All participants endorsed \u2018pharmacy is the right location for receiving methadone for MMT\u2019, 88% endorsed \u2018convenient or very convenient to receive methadone at the pharmacy\u2019 and 88% were satisfied or very satisfied with the quality of treatment offered.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This feasibility trial has found pharmacy administration and dispensing of physician\u2010prescribed methadone for methadone maintenance treatment to be feasible and acceptable.<\/jats:p><\/jats:sec>","DOI":"10.1111\/add.15641","type":"journal-article","created":{"date-parts":[[2021,7,19]],"date-time":"2021-07-19T14:04:51Z","timestamp":1626703491000},"page":"444-456","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Opioid treatment program and community pharmacy collaboration for methadone maintenance treatment: results from a feasibility clinical trial"],"prefix":"10.1111","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5909-2259","authenticated-orcid":false,"given":"Li\u2010Tzy","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences Duke University School of Medicine  Durham NC USA"},{"name":"Department of Medicine, Division of General Internal Medicine Duke University School of Medicine  Durham NC USA"},{"name":"Center for Child and Family Policy, Sanford School of Public Policy Duke University  Durham NC USA"},{"name":"Duke Institute For Brain Sciences Duke University  Durham NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William S.","family":"John","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences Duke University School of Medicine  Durham NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric D.","family":"Morse","sequence":"additional","affiliation":[{"name":"Morse Clinics  Raleigh NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Adkins","sequence":"additional","affiliation":[{"name":"Health Park Pharmacy  Raleigh NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Pippin","sequence":"additional","affiliation":[{"name":"Health Park Pharmacy  Raleigh NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert K.","family":"Brooner","sequence":"additional","affiliation":[{"name":"Johns Hopkins University School of Medicine  Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert P.","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Friends Research Institute, Inc  Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,16]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"Centers for Disease Control and Prevention (CDC).2020.Increase in Fatal Drug Overdoses Across the United States Driven by Synthetic Opioids Before and During the COVID\u201019 Pandemic. 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