{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:15:28Z","timestamp":1790252128193,"version":"4.1.0"},"reference-count":66,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T00:00:00Z","timestamp":1631059200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100008625","name":"GambleAware","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016030","name":"International Center for Responsible Gaming","doi-asserted-by":"publisher","award":["Center of Excellence award"],"award-info":[{"award-number":["Center of Excellence award"]}],"id":[{"id":"10.13039\/100016030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["T32AA\u2010013526"],"award-info":[{"award-number":["T32AA\u2010013526"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction"],"published-print":{"date-parts":[[2022,3]]},"abstract":"Abstract<\/jats:title>\n \n Background and Aims<\/jats:title>\n Previous research has demonstrated phenotypical associations between disordered gambling (DG) and Big 5 personality traits, and a twin study suggested that shared genetic influences accounted for a substantial portion of this relation. The present study examined associations between DG and polygenic scores (PSs) for Big 5 traits to measure the shared genetic underpinnings of Big 5 personality traits and DG.<\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n Zero\u2010inflated negative binomial regression models estimated associations between Big 5 PSs and past\u2010year and life\u2010time assessments of DG in a longitudinally assessed population\u2010based birth cohort.<\/jats:p>\n <\/jats:sec>\n \n Setting<\/jats:title>\n United Kingdom.<\/jats:p>\n <\/jats:sec>\n \n Participants<\/jats:title>\n A total of 4729 unrelated children of European ancestry from the Avon Longitudinal Study of Parents and Children (ALSPAC) with both phenotypical and genetic data.<\/jats:p>\n <\/jats:sec>\n \n Measurements<\/jats:title>\n Phenotypical outcomes included past\u2010year assessment of DG using the problem gambling severity index (PGSI) and life\u2010time assessment of DSM\u2010IV pathological gambling symptoms (DPG) across the ages of 17, 20 and 24\u2009years. Polygenic scores were derived for the Big 5 personality traits of agreeableness, extraversion, conscientiousness, openness and neuroticism using summary statistics from genome\u2010wide association studies (GWAS).<\/jats:p>\n <\/jats:sec>\n \n Findings<\/jats:title>\n \n PSs for agreeableness [\n \u03b2<\/jats:italic>\n =\u2009\u2212\u20090.25, standard error (SE)\u2009=\u20090.054,\n P<\/jats:italic>\n \u2009=\u20093.031e\u20106, \u0394\n R<\/jats:italic>\n 2<\/jats:sup>\n \u2009=\u20090.008] and neuroticism (\n \u03b2<\/jats:italic>\n =0.14, SE\u2009=\u20090.046,\n P<\/jats:italic>\n \u2009=\u20090.0017, \u0394\n R<\/jats:italic>\n 2<\/jats:sup>\n \u2009=\u20090.002) significantly predicted PGSI scores over and above included covariates (i.e. sex and first five ancestral principal components). PSs for agreeableness (\n \u03b2<\/jats:italic>\n =\u2009\u2212\u20090.20, SE\u2009=\u20090.056,\n P<\/jats:italic>\n \u2009=\u20090.00036, \u0394\n R<\/jats:italic>\n 2<\/jats:sup>\n \u2009=\u20090.003) and neuroticism, when interactions with age were taken into account (\n \u03b2<\/jats:italic>\n \u2009=\u20090.29, SE\u2009=\u20090.090,\n P<\/jats:italic>\n \u2009=\u20090.002, \u0394\n R<\/jats:italic>\n 2<\/jats:sup>\n \u2009=\u20090.004), also predicted DPG scores.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Polygenic contributions to low agreeableness and high neuroticism appear to predict two measures of disordered gambling (problem gambling severity index and life\u2010time assessment of DSM\u2010IV pathological gambling symptoms). Polygenic scores for neuroticism interact with age to suggest that the positive association becomes stronger from adolescence through young adulthood.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/add.15648","type":"journal-article","created":{"date-parts":[[2021,8,3]],"date-time":"2021-08-03T04:39:03Z","timestamp":1627965543000},"page":"690-700","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Predicting disordered gambling across adolescence and young adulthood from polygenic contributions to Big 5 personality traits in a UK birth cohort"],"prefix":"10.1111","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9046-6848","authenticated-orcid":false,"given":"Kellyn M.","family":"Spychala","sequence":"first","affiliation":[{"name":"Department of Psychological Sciences University of Missouri Columbia MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian R.","family":"Gizer","sequence":"additional","affiliation":[{"name":"Department of Psychological Sciences University of Missouri Columbia MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christal N.","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Psychological Sciences University of Missouri Columbia MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4394-0700","authenticated-orcid":false,"given":"Genevieve F.","family":"Dash","sequence":"additional","affiliation":[{"name":"Department of Psychological Sciences University of Missouri Columbia MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2793-2049","authenticated-orcid":false,"given":"Thomas M.","family":"Piasecki","sequence":"additional","affiliation":[{"name":"Department of Psychological Sciences University of Missouri Columbia MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4502-6936","authenticated-orcid":false,"given":"Wendy S.","family":"Slutske","sequence":"additional","affiliation":[{"name":"Department of Psychological Sciences University of Missouri Columbia MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-019-0099-7"},{"key":"e_1_2_9_3_1","first-page":"73","volume-title":"Genetic and environmental contributions to risk for disordered gambling. 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