{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:11:26Z","timestamp":1787242286735,"version":"build-2736575974"},"reference-count":65,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,11,6]],"date-time":"2021-11-06T00:00:00Z","timestamp":1636156800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100012774","name":"Innovationsfonden","doi-asserted-by":"publisher","award":["603\u201000520B."],"award-info":[{"award-number":["603\u201000520B."]}],"id":[{"id":"10.13039\/100012774","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To estimate the risks of 12 types of somatic disease\u2014alcohol\u2010related, blood, cancer, circulatory, digestive, endocrine and metabolic, genitourinary, infectious, musculoskeletal, nervous, respiratory and skin\u2014in individuals with parental alcohol use disorder (AUD) versus a reference population, and to estimate the risks of all\u2010cause mortality and of death from an alcohol\u2010related cause.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Matched cohort study followed\u2010up through nation\u2010wide health registries. Cox proportional hazards models were used to estimate hazard ratios (HRs) with 95% confidence intervals (CIs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Denmark.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>A total of 14\u2009008 individuals born 1962\u20132003 of parents with AUD and 139\u2009087 reference offspring randomly selected from the Danish Civil Registration System were followed from their 15th birthday and onward during 1970\u20132018. Follow\u2010up time ranged between 2\u2009423\u2009955 and 3\u2009208\u2009366 person\u2010years for somatic diseases and was 3\u2009214\u2009411 person\u2010years for all\u2010cause and alcohol\u2010related mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements<\/jats:title>\n                    <jats:p>Information on somatic disease was obtained from the Danish National Patient Registry. Causes of death were obtained from the Danish Cause of Death Registry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Findings<\/jats:title>\n                    <jats:p>Individuals of parents with AUD had a higher risk of alcohol\u2010related diseases (HR\u2009=\u20092.70, 95% CI\u2009=\u20092.24\u20133.24) compared with the reference individuals. Higher HRs among individuals with parental AUD compared with reference individuals were also observed in all other somatic diseases except for cancer. All\u2010cause mortality (HR\u2009=\u20091.80, 95% CI\u2009=\u20091.63\u20132.00) and alcohol\u2010related mortality (HR\u2009=\u20093.28, 95% CI\u2009=\u20092.11\u20135.08) were higher among individuals of parents with AUD compared with the reference individuals. No significant differences were found in relation to the gender of either parents or offspring.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In Denmark, parental alcohol use disorder appears to predict alcohol\u2010related and non\u2010alcohol\u2010related somatic morbidity and mortality in offspring.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/add.15722","type":"journal-article","created":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T23:15:59Z","timestamp":1635203759000},"page":"905-912","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Risk of somatic disease and mortality in individuals of parents with alcohol use disorder: a register\u2010based cohort study"],"prefix":"10.1111","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1189-038X","authenticated-orcid":false,"given":"Charlotte","family":"Holst","sequence":"first","affiliation":[{"name":"National Institute of Public Health University of Southern Denmark  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9796-3967","authenticated-orcid":false,"given":"Janne S.","family":"Tolstrup","sequence":"additional","affiliation":[{"name":"National Institute of Public Health University of Southern Denmark  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1678-7771","authenticated-orcid":false,"given":"Ulrik","family":"Becker","sequence":"additional","affiliation":[{"name":"National Institute of Public Health University of Southern Denmark  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-12-448"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/add.13508"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10826-014-9930-7"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2013.02.024"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0740-5472(03)00116-8"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s007870070046"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00787-018-1253-6"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1017\/thg.2016.62"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291714002165"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2014.2138"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0049655"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2011.01467.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.13m08350"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/acps.13002"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3109\/10826084.2011.648044"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/dar.12121"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m853"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/02699050701553221"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2014.579"},{"key":"e_1_2_8_21_1","first-page":"387","article-title":"Alcohol as a risk factor for pancreatitis. 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