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This review describes the diagnosis, prevalence, course and management of cannabis withdrawal and highlights opportunities for future clinical research.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Narrative review of literature.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Symptom onset typically occurs 24\u201348\u2009hours after cessation and most symptoms generally peak at days 2\u20136, with some symptoms lasting up to 3\u00a0weeks or more in heavy cannabis users. The most common features of cannabis withdrawal are anxiety, irritability, anger or aggression, disturbed sleep\/dreaming, depressed mood and loss of appetite. Less common physical symptoms include chills, headaches, physical tension, sweating and stomach pain. Despite limited empirical evidence, supportive counselling and psychoeducation are the first\u2010line approaches in the management of cannabis withdrawal. There are no medications currently approved specifically for medically assisted withdrawal (MAW). Medications have been used to manage short\u2010term symptoms (e.g. anxiety, sleep, nausea). A number of promising pharmacological agents have been examined in controlled trials, but these have been underpowered and positive findings not reliably replicated. Some (e.g. cannabis agonists) are used \u2018off\u2010label\u2019 in clinical practice. Inpatient admission for MAW may be clinically indicated for patients who have significant comorbid mental health disorders and polysubstance use to avoid severe complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The clinical significance of cannabis withdrawal is that its symptoms may precipitate relapse to cannabis use. Complicated withdrawal may occur in people with concurrent mental health and polysubstance use.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/add.15743","type":"journal-article","created":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T01:30:17Z","timestamp":1637199017000},"page":"2075-2095","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":113,"title":["Clinical management of cannabis withdrawal"],"prefix":"10.1111","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7020-1196","authenticated-orcid":false,"given":"Jason P.","family":"Connor","sequence":"first","affiliation":[{"name":"National Centre for Youth Substance Use Research The University of Queensland  St Lucia QLD Australia"},{"name":"Discipline of Psychiatry, Faculty of Medicine The University of Queensland  Herston QLD 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