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This systematic review aimed to identify and critically assess full economic evaluations for tobacco control interventions in low\u2010 and middle\u2010income countries.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Electronic databases, including EMBASE, MEDLINE and PsycINFO and the grey literature, were searched using terms such as \u2018tobacco\u2019, \u2018economic evaluation\u2019 and \u2018smoking\u2019 from 1994 to 2020. Study quality was assessed using the Consensus Health Economic Criteria and the Philips checklist. Studies were included which were full economic evaluations of tobacco control interventions in low\u2010 and middle\u2010income settings. Reviews, commentaries, conference proceedings and abstracts were excluded. Study selection and quality assessment were conducted by two reviewers independently. A narrative synthesis was conducted to synthesize the findings of the studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>This review identified 20 studies for inclusion. The studies evaluated a wide range of interventions, including tax increase, nicotine replacement therapy (nicotine patch\/gum) and financial incentives. Overall, 12 interventions were reported to be cost\u2010effective, especially tax increases for tobacco consumption and cessation counselling. There were considerable limitations regarding data sources (e.g. using cost data from other countries or assumptions due to the lack of local data) and the model structure; sensitivity analyses were inadequately described in many studies; and there were issues around the transferability of results to other settings. Additionally, the affordability of the interventions was only discussed in two studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There are few high\u2010quality studies of the cost\u2010effectiveness of tobacco use control interventions in low\u2010 and middle\u2010income countries. The methodological limitations of the existing literatures could affect the generalizability of the findings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/add.15821","type":"journal-article","created":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T09:12:25Z","timestamp":1646730745000},"page":"2374-2392","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Economic evaluations of tobacco control interventions in low\u2010 and middle\u2010income countries: a systematic review"],"prefix":"10.1111","volume":"117","author":[{"given":"Xiaobin","family":"Jiang","sequence":"first","affiliation":[{"name":"Health Economics Unit, Institute of Applied Health Research University of Birmingham  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8492-0020","authenticated-orcid":false,"given":"Louise J.","family":"Jackson","sequence":"additional","affiliation":[{"name":"Health Economics Unit, Institute of Applied Health Research University of Birmingham  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4372-1935","authenticated-orcid":false,"given":"Muslim Abbas","family":"Syed","sequence":"additional","affiliation":[{"name":"Health Economics Unit, Institute of Applied Health Research University of Birmingham  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4143-3852","authenticated-orcid":false,"given":"Tuba Sayg\u0131n","family":"Av\u015far","sequence":"additional","affiliation":[{"name":"Department of Applied Health Research University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2736-5427","authenticated-orcid":false,"given":"Zainab","family":"Abdali","sequence":"additional","affiliation":[{"name":"Health Economics Unit, Institute of Applied Health Research University of Birmingham  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,8]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"World Health Organization (WHO)WHO Tobacco Fact Sheet. 2020. 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