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Prior studies examining associations between transdermal alcohol concentration (TAC) and blood\/breath alcohol concentration (BAC) have yielded highly variable correlations and lag times. The current review aimed to synthesize transdermal validation studies, aggregating results from more than three decades of research to characterize the validity of transdermal sensors for assessing alcohol consumption.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Databases were searched for studies listed prior to 1 March 2022 that examined associations between transdermal alcohol sensor output and blood and breath\u2010based alcohol measures, resulting in 31 primarily laboratory\u2010derived participant samples (27 precise effect sizes) including both healthy and clinical populations. Correlation coefficients and lag times were pooled using three\u2010level random\u2010effects meta\u2010regression. Independent raters coded study characteristics, including the body position of transdermal sensors (ankle\u2010 versus arm\/hand\/wrist\u2010worn device) and methodological bias (e.g. missing data).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Analyses revealed that, in this primarily laboratory\u2010derived sample of studies, the average correlation between TAC and BAC was large in magnitude [<jats:italic>r<\/jats:italic>\u2009=\u20090.87, 95% confidence interval (CI)\u2009=\u20090.80, 0.93], and TAC lagged behind BAC by an average of 95.90\u2009minutes (95% CI\u2009=\u200955.50, 136.29). Device body position significantly moderated both TAC\u2013BAC correlation (<jats:italic>b<\/jats:italic>\u2009=\u20090.11, <jats:italic>P<\/jats:italic>\u2009=\u20090.009) and lag time (<jats:italic>b<\/jats:italic>\u2009=\u2009\u221269.41, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Lag times for ankle\u2010worn devices were approximately double those for arm\/hand\/wrist\u2010worn devices, and TAC\u2013BAC correlations also tended to be stronger for arm\/hand\/wrist\u2010worn sensors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This meta\u2010analysis indicates that transdermal alcohol sensors perform strongly in assessing blood\/breath alcohol concentration under controlled conditions, with particular promise for the newer generation of wrist\u2010worn devices.<\/jats:p><\/jats:sec>","DOI":"10.1111\/add.15953","type":"journal-article","created":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T10:34:13Z","timestamp":1653302053000},"page":"2805-2815","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Validating transdermal alcohol biosensors: a meta\u2010analysis of associations between blood\/breath\u2010based measures and transdermal alcohol sensor output"],"prefix":"10.1111","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7731-0563","authenticated-orcid":false,"given":"Jiachen","family":"Yu","sequence":"first","affiliation":[{"name":"University of Illinois, Urbana\u2010Champaign  IL USA"},{"name":"Division of the Social Sciences University of Chicago  Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2694-5585","authenticated-orcid":false,"given":"Catharine E.","family":"Fairbairn","sequence":"additional","affiliation":[{"name":"University of Illinois, Urbana\u2010Champaign  IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8382-7254","authenticated-orcid":false,"given":"Laura","family":"Gurrieri","sequence":"additional","affiliation":[{"name":"University of Illinois, Urbana\u2010Champaign  IL USA"},{"name":"Department of Psychology Georgia State University  Atlanta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eddie P.","family":"Caumiant","sequence":"additional","affiliation":[{"name":"University of Illinois, Urbana\u2010Champaign  IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,6,12]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"13","article-title":"Measuring alcohol in blood and breath for forensic purposes: a historical review","volume":"8","author":"Jones AW","year":"1996","journal-title":"Forensic Sci Rev"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1359-6357.2003.00605.x"},{"key":"e_1_2_8_4_1","first-page":"26","article-title":"The role of breathalyzer test for understanding drinkers\u2019 patterns and behaviors: a study conducted in Porto party settings","volume":"63","author":"Carvalho HM","year":"2019","journal-title":"J Alcohol Drug Educ"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13722-019-0174-0"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.13975"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1037\/0003-066X.54.2.93"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3109\/10826089409128263"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/dar.12558"},{"key":"e_1_2_8_10_1","first-page":"186","article-title":"What happened? 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