{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:39:27Z","timestamp":1772159967694,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,6,12]],"date-time":"2022-06-12T00:00:00Z","timestamp":1654992000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To quantify the healthcare costs associated with opioid use disorder among members in a public healthcare system and compare them with healthcare costs in the general population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Retrospective cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Inpatient and outpatient care settings of Israel's largest public healthcare provider (that covers 4.7 million members).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>Participants included 1173 members who had a diagnosis of opioid use disorder in the years between 2013 and 2018. Each patient was matched with 10 controls based on age and sex.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements<\/jats:title>\n                    <jats:p>The main outcome was monthly healthcare costs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Findings<\/jats:title>\n                    <jats:p>The mean monthly healthcare cost of members with opioid use disorder was $1102 compared with $211 among controls (5.2\u2010fold difference; 95% CI, 4.6\u20136.0). After excluding members with heroin related diagnoses before the index date (to focus on prescription opioids), this healthcare cost ratio did not substantially change (4.6\u2010fold; 95% CI, 3.9\u20135.4). Members with opioid use disorder under the age of 65\u2009years had a cost difference of 6.1\u2010fold (95% CI, 5.2\u20137.1), whereas those 65\u2009years and older experienced cost difference of 3.4\u2010fold (95% CI, 2.6\u20134.5), compared with controls. The category with the highest cost for members with opioid use disorder was inpatient services, which was 8.7\u2010fold (95%CI, 7.2\u201310.4) greater than among controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Healthcare costs among individuals with opioid use disorder in Israel's public health system are substantially higher than among controls, at least partially attributable to prescription opioid use disorder. Differences are greater among individuals under 65\u2009years.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/add.15963","type":"journal-article","created":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T04:48:55Z","timestamp":1653972535000},"page":"2880-2886","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Association of opioid use disorder with healthcare utilization and cost in a public health system"],"prefix":"10.1111","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7742-478X","authenticated-orcid":false,"given":"Oren","family":"Miron","sequence":"first","affiliation":[{"name":"Clalit Research Institute Clalit Health Services  Ramat Gan Israel"},{"name":"School of Public Health Ben\u2010Gurion University of the Negev  Beer Sheva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noam","family":"Barda","sequence":"additional","affiliation":[{"name":"ARC Innovation Center Sheba Medical Center  Ramat\u2010Gan Israel"},{"name":"Software and Information Systems Engineering Ben\u2010Gurion University of the Negev  Beer Sheva Israel"},{"name":"Department of Biomedical Informatics Harvard Medical School  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ran","family":"Balicer","sequence":"additional","affiliation":[{"name":"Clalit Research Institute Clalit Health Services  Ramat Gan Israel"},{"name":"School of Public Health Ben\u2010Gurion University of the Negev  Beer Sheva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ariel","family":"Kor","sequence":"additional","affiliation":[{"name":"Israel Center on Addiction  Netanya Israel"},{"name":"Yale University School of Medicine  New Haven CT USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaul","family":"Lev\u2010Ran","sequence":"additional","affiliation":[{"name":"Israel Center on Addiction  Netanya Israel"},{"name":"Department of Psychiatry, Sackler Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,6,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2016-2387"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6450a3"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e3181c38c25"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2018.07.034"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2010.04.018"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsat.2016.05.002"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2020.108382"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.18553\/jmcp.2005.11.6.469"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/add.15571"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/add.14947"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1360-0443.2003.00430.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1360-0443.2002.00170.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/add.15222"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.4415"},{"key":"e_1_2_8_16_1","first-page":"1","article-title":"Rising opioid prescription fulfillment among non\u2010cancer and non\u2010elderly patients\u2014Israel's alarming example","author":"Miron O","year":"2020","journal-title":"Reg Anesth Pain Med"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-018-1058-y"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.2147\/CEOR.S85213"},{"key":"e_1_2_8_19_1","unstructured":"Characterization and Classification of Geographical Units by the Socio\u2010Economic Level of the Population.https:\/\/www.cbs.gov.il\/en\/mediarelease\/Pages\/2020\/Characterization-Classification-GeographicalUnitsby-Socio-Economic-Level-Population2017.aspx(2017). Aaccessed 10 Jan 2021."},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/papr.12147"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2021.108568"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)32229-9"},{"key":"e_1_2_8_23_1","unstructured":"Nigmalim.Estimate: 15 000 Israelies are addicted to prescription opioids. Nigmalim.https:\/\/www.nigmalim.co.il(2017). Accessed 6 Jan 2022."},{"key":"e_1_2_8_24_1","unstructured":"\u2018Everyone Knows Somebody\u2019: The opioid epidemic among Israel's orthodox \u2010 The Jerusalem Post.https:\/\/www.jpost.com\/israel-news\/everyone-knows-somebody-the-opioid-epidemic-among-israels-orthodox-608942Accessed 6 Jan 2022."},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2021.108583"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1162\/ajhe_a_00113"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2008.02358.x"}],"container-title":["Addiction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/add.15963","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/add.15963","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/add.15963","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T06:11:41Z","timestamp":1692598301000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/add.15963"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,12]]},"references-count":26,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["10.1111\/add.15963"],"URL":"https:\/\/doi.org\/10.1111\/add.15963","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.06.15.21258943","asserted-by":"object"}]},"ISSN":["0965-2140","1360-0443"],"issn-type":[{"value":"0965-2140","type":"print"},{"value":"1360-0443","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,12]]},"assertion":[{"value":"2021-10-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}