{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T04:08:51Z","timestamp":1773288531568,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,7,5]],"date-time":"2022-07-05T00:00:00Z","timestamp":1656979200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Topiramate is a medication that is widely prescribed to treat a variety of conditions, including alcohol use disorder (AUD). We used electronic health record (EHR) data to measure topiramate's effects on drinking in individuals differentiated by a history of AUD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Parallel\u2010groups comparison of patients prescribed topiramate and a propensity score\u2010matched comparison group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>A large US integrated health\u2010care system.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>Patients with Alcohol Use Disorders Identification Test\u2013Consumption (AUDIT\u2010C) scores prior to and after a minimum of 180\u2009days of topiramate prescription for any indication and a propensity score\u2010matched group. The sample included 5918 patients with an electronic health record diagnosis of alcohol use disorder at any time (AUD\u2010hx\u2010pos) (1738 topiramate\u2010exposed and 4180 controls) and 23\u2009614 patients with no EHR diagnosis of AUD (AUD\u2010hx\u2010neg) (6324 topiramate\u2010exposed and 17\u2009290 controls).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements<\/jats:title>\n                    <jats:p>Regression analyses compared difference\u2010in\u2010difference (DiD) estimates, separately by AUD history. DiD estimates represent exposure\u2010group (i.e. topiramate versus control) differences on the pre\u2013post difference in AUDIT\u2010C score. Effects of baseline AUDIT\u2010C score and daily topiramate dosage were also tested.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Findings<\/jats:title>\n                    <jats:p>\n                      AUD\u2010hx\u2010neg patients who received topiramate had a greater reduction in AUDIT\u2010C score (\u22120.11) than matched controls (\u22120.04). This yielded a DiD score of \u22120.07 [95% confidence interval (CI)\u2009=\u2009\u22120.11,\u20100.03;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.002], with the greatest effect among AUD\u2010hx\u2010neg patients with a baseline AUDIT\u2010C score of 4+\u2009(DiD\u2009=\u2009\u22120.35, 95% CI\u2009=\u2009\u20130.49, \u22120.21;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.0001) and those prescribed &gt;\u2009150\u2009mg\/day of the medication (DiD\u2009=\u2009\u22120.15, 95%CI\u2009=\u2009\u20130.23, \u22120.07;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Among individuals with no history of alcohol use disorder, topiramate appears to be associated with reduced drinking. This small effect is most evident among patients with higher baseline drinking levels and at a higher average daily topiramate dosage.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/add.15980","type":"journal-article","created":{"date-parts":[[2022,6,30]],"date-time":"2022-06-30T01:03:39Z","timestamp":1656551019000},"page":"2826-2836","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Association of topiramate prescribed for any indication with reduced alcohol consumption in electronic health record data"],"prefix":"10.1111","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1018-0450","authenticated-orcid":false,"given":"Henry R.","family":"Kranzler","sequence":"first","affiliation":[{"name":"Mental Illness Research, Education and Clinical Center Crescenz Veterans Affairs Medical Center  Philadelphia PA USA"},{"name":"Department of Psychiatry University of Pennsylvania Perelman School of Medicine  Philadelphia PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shirley H.","family":"Leong","sequence":"additional","affiliation":[{"name":"Mental Illness Research, Education and Clinical Center Crescenz Veterans Affairs Medical Center  Philadelphia PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Naps","sequence":"additional","affiliation":[{"name":"Mental Illness Research, Education and Clinical Center Crescenz Veterans Affairs Medical Center  Philadelphia PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5137-9714","authenticated-orcid":false,"given":"Emily E.","family":"Hartwell","sequence":"additional","affiliation":[{"name":"Mental Illness Research, Education and Clinical Center Crescenz Veterans Affairs Medical Center  Philadelphia PA USA"},{"name":"Department of Psychiatry University of Pennsylvania Perelman School of Medicine  Philadelphia PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4006-010X","authenticated-orcid":false,"given":"David A.","family":"Fiellin","sequence":"additional","affiliation":[{"name":"Department of Medicine Yale School of Medicine  New Haven CT USA"},{"name":"Department of Health Policy and Management Yale School of Public Health  New Haven CT USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1408-7907","authenticated-orcid":false,"given":"Christopher T.","family":"Rentsch","sequence":"additional","affiliation":[{"name":"Department of Medicine Yale School of Medicine  New Haven CT USA"},{"name":"VA Connecticut Healthcare System US Department of Veterans Affairs  West Haven CT USA"},{"name":"Faculty of Epidemiology and Population Health London School of Hygiene and Tropical Medicine  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,7,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.13157"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2017.12.026"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2018.07.017"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2019.0447"},{"key":"e_1_2_8_6_1","unstructured":"KaneSP.Topiramate ClinCalc DrugStats Database version 21.1. 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