{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:34:35Z","timestamp":1747182875633,"version":"3.40.5"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,12,27]],"date-time":"2022-12-27T00:00:00Z","timestamp":1672099200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["R01 DA030005"],"award-info":[{"award-number":["R01 DA030005"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["K01AA024152"],"award-info":[{"award-number":["K01AA024152"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006636","name":"Forskningsr\u00e5det om H\u00e4lsa, Arbetsliv och V\u00e4lf\u00e4rd","doi-asserted-by":"publisher","award":["2020\u201001175"],"award-info":[{"award-number":["2020\u201001175"]}],"id":[{"id":"10.13039\/501100006636","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009780","name":"Region Sk\u00e5ne","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Preclinical and human studies suggest that a social partner's genotype may be associated with addiction\u2010related outcomes. This study measured whether spousal genetic makeup is associated with risk of developing drug use disorder (DUD) during marriage and whether the risk associated with a spouse's genotype could be disentangled from potentially confounding rearing environmental effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Univariable and multivariable logistic regression analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Sweden.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>Men and women born between 1960 and 1990 and in opposite\u2010sex first marriages before age 35 (<jats:italic>n<\/jats:italic>\u2009=\u2009294\u2009748 couples).<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements<\/jats:title><jats:p>Outcome was DUD diagnosis (inclusive of opioids, sedatives\/hypnotics\/anxiolytics, cocaine, cannabis, amphetamine and other psychostimulants, hallucinogens, other drugs of abuse and combinations thereof) obtained from legal, medical and pharmacy registries. The focal predictor was family genetic risk scores for DUD (FGRS\u2010DUD), which were inferred from diagnoses in first\u2010 through fifth\u2010degree relatives and weighted by degree of genetic sharing. FGRS\u2010DUD were calculated separately for each partner in a couple.<\/jats:p><\/jats:sec><jats:sec><jats:title>Findings<\/jats:title><jats:p>Marriage to a spouse with a high FGRS\u2010DUD was associated with increased risk of developing DUD during marriage, OR<jats:sub>males<\/jats:sub>\u2009=\u20091.68 (95% CI\u2009=\u20091.50, 1.88) and OR<jats:sub>females<\/jats:sub>\u2009=\u20091.35 (1.16, 1.56), above and beyond the risk associated with one's own FGRS\u2010DUD. The risk associated with a spouse's FGRS\u2010DUD remained statistically significant after covarying for parental education. As indicated by a series of null interaction effects, there was no evidence that the risk associated with a spouse's FGRS\u2010DUD differed depending on whether the spouse was DUD\u2010affected, probands' probable contact with in\u2010laws and whether the spouse was raised by his\/her biological parents or in another home.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There is relatively robust evidence that a person's risk for developing drug use disorder is associated with the genetic makeup of the person's spouse.<\/jats:p><\/jats:sec>","DOI":"10.1111\/add.16108","type":"journal-article","created":{"date-parts":[[2022,12,10]],"date-time":"2022-12-10T01:19:00Z","timestamp":1670635140000},"page":"880-889","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Social genetic effects for drug use disorder among spouses"],"prefix":"10.1111","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5504-5087","authenticated-orcid":false,"given":"Jessica E.","family":"Salvatore","sequence":"first","affiliation":[{"name":"Department of Psychiatry Rutgers Robert Wood Johnson Medical School  Piscataway NJ USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Larsson L\u00f6nn","sequence":"additional","affiliation":[{"name":"Center for Primary Health Care Research Lund University  Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Sundquist","sequence":"additional","affiliation":[{"name":"Center for Primary Health Care Research Lund University  Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8689-6570","authenticated-orcid":false,"given":"Kenneth S.","family":"Kendler","sequence":"additional","affiliation":[{"name":"Virginia Institute for Psychiatric and Behavioral Genetics Virginia Commonwealth University  Richmond VA USA"},{"name":"Department of Psychiatry Virginia Commonwealth University  Richmond VA USA"},{"name":"Department of Human and Molecular Genetics Virginia Commonwealth University  Richmond VA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristina","family":"Sundquist","sequence":"additional","affiliation":[{"name":"Center for Primary Health Care Research Lund University  Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,12,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(18)30337-7"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1037\/10107-000"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2017.06.036"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2012.54"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1806901116"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1006498"},{"key":"e_1_2_8_8_1","first-page":"661","article-title":"Attachment and dyadic regulation processes","volume":"1","author":"Overall NC","year":"2015","journal-title":"Curr Opin Psychol"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-5834.1994.tb01285.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-019-0607-x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"crossref","unstructured":"MandemakersJ. 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