{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T23:26:51Z","timestamp":1768346811304,"version":"3.49.0"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,1,12]],"date-time":"2023-01-12T00:00:00Z","timestamp":1673481600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>The Veterans Health Administration (VHA) implemented the Stratification Tool for Opioid Risk Mitigation (STORM) to reduce the risk of serious adverse events (SAE) among patients with opioid analgesic prescriptions. VHA facilities were mandated to case review patients identified as high risk by STORM. The aim of this study was to measure the effect of this mandate on all\u2010cause mortality and SAEs among VHA patients newly diagnosed with opioid use disorder (OUD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Secondary analysis of a stepped\u2010wedged cluster randomized controlled trial conducted at all 140 VHA facilities, with facility as the unit of randomization, from 2018 to 2020.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting and Participants<\/jats:title><jats:p>United States VHA facilities were randomized to case review the top 1 or 5% of high\u2010risk patients prescribed opioid analgesics identified by STORM. A total of 28\u2009251 patients were diagnosed with OUD during the trial and were considered control or treatment depending on the status of the facility where they received their OUD diagnosis. <jats:italic>Post\u2010hoc<\/jats:italic> analyses among patients who had at least one opioid analgesic prescription in the 90\u2009days prior to diagnosis were conducted and were then stratified by receipt of a prescription in the 90\u2009days following diagnosis to assess the sensitivity of results to opioid discontinuation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements<\/jats:title><jats:p>All\u2010cause mortality and opioid\u2010related, drug\u2010related, suicide\u2010related and other SAEs within 90\u2009days of OUD diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Findings<\/jats:title><jats:p>Mandated case review increased the odds of 90\u2010day mortality [odds ratio (OR)\u2009=\u20091.74, 95% confidence interval (CI)\u2009=\u20091.06, 2.87], but did not significantly change the odds of SAEs. Among patients who received an opioid prescription prior to but not after OUD diagnosis, the odds of all\u2010cause mortality within 90\u2009days was 5.87 (95% CI\u2009=\u20091.85, 18.58) relative to control patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Veterans Health Administration patients newly diagnosed with opioid use disorder experienced increased all\u2010cause mortality following expansion of a case review mandate for high\u2010risk patients prescribed opioids.<\/jats:p><\/jats:sec>","DOI":"10.1111\/add.16110","type":"journal-article","created":{"date-parts":[[2022,12,10]],"date-time":"2022-12-10T16:24:02Z","timestamp":1670689442000},"page":"870-879","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effect of a Veterans Health Administration mandate to case review patients with opioid prescriptions on mortality among patients with opioid use disorder: a secondary analysis of the STORM randomized control trial"],"prefix":"10.1111","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0776-4025","authenticated-orcid":false,"given":"Samantha G.","family":"Auty","sequence":"first","affiliation":[{"name":"Department of Health Law, Policy and Management Boston University School of Public Health  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyle D.","family":"Barr","sequence":"additional","affiliation":[{"name":"Partnered Evidence\u2010Based Policy Resource Center Veterans Administration Boston Healthcare System  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Austin B.","family":"Frakt","sequence":"additional","affiliation":[{"name":"Department of Health Law, Policy and Management Boston University School of Public Health  Boston MA USA"},{"name":"Partnered Evidence\u2010Based Policy Resource Center Veterans Administration Boston Healthcare System  Boston MA USA"},{"name":"Department of Health Policy and Management Harvard T.H. Chan School of Public Health  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa M.","family":"Garrido","sequence":"additional","affiliation":[{"name":"Department of Health Law, Policy and Management Boston University School of Public Health  Boston MA USA"},{"name":"Partnered Evidence\u2010Based Policy Resource Center Veterans Administration Boston Healthcare System  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7457-7211","authenticated-orcid":false,"given":"Kiersten L.","family":"Strombotne","sequence":"additional","affiliation":[{"name":"Department of Health Law, Policy and Management Boston University School of Public Health  Boston MA USA"},{"name":"Partnered Evidence\u2010Based Policy Resource Center Veterans Administration Boston Healthcare System  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,1,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-018-0670-z"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11606-020-06267-2"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.rr6902a1"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.7326\/M18-0883"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsat.2020.108032"},{"key":"e_1_2_9_7_1","first-page":"1","article-title":"Adoption of the 275\u2010patient buprenorphine treatment waiver for treating opioid use disorder: a state\u2010level longitudinal analysis","volume":"11","author":"Knudsen HK","year":"2019","journal-title":"Subst Abuse"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.170363"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000837"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLR.0b013e318202aa27"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2019.01.016"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1037\/ser0000099"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/08897077.2018.1540376"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.11013"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/add.14991"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1089\/pop.2013.0098"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/08897077.2018.1452327"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11606-022-07617-y"},{"key":"e_1_2_9_19_1","article-title":"County\u2010level impact of the COVID\u201019 pandemic on excess mortality among U.S. veterans: a population\u2010based study","volume":"5","author":"Feyman Y","year":"2021","journal-title":"Lancet Reg Health Am"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-015-0842-7"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11606-021-07086-9"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLR.0000000000000326"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.1954"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsat.2019.05.001"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/pm\/pny124"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/geront\/gnaa016"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhealeco.2020.102408"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2017.2468"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1080\/08897077.2020.1787299"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1377\/hblog20140307.037362"},{"key":"e_1_2_9_31_1","volume-title":"FDA identifies harm reported from sudden discontinuation of opioid pain medicines and requires label changes to guide prescribers on gradual, individualized tapering","year":"2019"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ypmed.2019.05.028"}],"container-title":["Addiction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/add.16110","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/add.16110","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/add.16110","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T03:00:45Z","timestamp":1692586845000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/add.16110"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,12]]},"references-count":31,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["10.1111\/add.16110"],"URL":"https:\/\/doi.org\/10.1111\/add.16110","archive":["Portico"],"relation":{},"ISSN":["0965-2140","1360-0443"],"issn-type":[{"value":"0965-2140","type":"print"},{"value":"1360-0443","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,12]]},"assertion":[{"value":"2022-02-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}