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This study reviewed research from peer\u2010reviewed and non\u2010peer\u2010reviewed (e.g. anecdotal and news) reports related to delta\u20108 THC to summarize current knowledge and implications for public health and safety.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A scoping review was conducted using PubMed, Scopus, Google Scholar and Google as search engines, leading to the identification of 103 documents that were summarized. The themes that emerged were (1) legality, (2) use (popularity, motives, psychoactivity\/potency, benefits\/consequences), (3) synthesis (byproducts, laboratory testing) and (4) retail (availability, price, packaging, youth\u2010oriented marketing). A second author independently coded 20% of the documents, which verified the categorization of articles by these emergent themes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Most research used animal\/cell models or focused upon ways to identify the chemical structure of delta\u20108 THC in various products. Findings suggest that people often use delta\u20108 THC as a substitute for other substances. Anecdotally, delta\u20108 THC is a less potent psychoactive than delta\u20109 THC; however, several negative consequences have been reported. There is no federal age restriction for purchase\/possession of delta\u20108 THC products. Delta\u20108 THC is readily accessible on\u2010line, is typically less expensive than delta\u20109 THC and is often marketed in ways that would seemingly appeal to children. There are no regulations on synthesis, resulting in products being contaminated and\/or yielding inconsistent effects. There have been thousands of calls to US poison control centers due to accidental delta\u20108 THC exposure among minors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Most research on delta\u20108 THC is largely anecdotal, not peer\u2010reviewed and does not involve human subjects. Future research should examine delta\u20108 THC use using nationally representative samples to more clearly understand the prevalence and consequences of use. Laws are needed to mitigate the risks of using delta\u20108 THC, particularly quality control of synthesis and minimum purchase age.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/add.16142","type":"journal-article","created":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T01:10:25Z","timestamp":1675041025000},"page":"1011-1028","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":73,"title":["Delta\u20108 tetrahydrocannabinol: a scoping review and commentary"],"prefix":"10.1111","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4206-4179","authenticated-orcid":false,"given":"Cassidy R.","family":"LoParco","sequence":"first","affiliation":[{"name":"School of Public Health University of North Texas Health Science Center  Fort Worth TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew E.","family":"Rossheim","sequence":"additional","affiliation":[{"name":"School of Public Health University of North Texas Health Science Center  Fort Worth TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott T.","family":"Walters","sequence":"additional","affiliation":[{"name":"School of Public Health University of North Texas Health Science Center  Fort Worth TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengyang","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of Public Health University of North Texas Health Science Center  Fort Worth TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Olsson","sequence":"additional","affiliation":[{"name":"School of Medicine Texas Christian University  Fort Worth TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve Y.","family":"Sussman","sequence":"additional","affiliation":[{"name":"Keck School of Medicine University of Southern California  Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,2,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/bkab029"},{"key":"e_1_2_9_3_1","first-page":"S0735","article-title":"The current state of delta\u20108 THC","volume":"56","author":"Johnson\u2010Arbor K","year":"2021","journal-title":"Am J Emerg Med"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugpo.2021.103557"},{"key":"e_1_2_9_5_1","unstructured":"Food and Drug Administration (FDA).5 things to know about delta\u20108 tetrahydrocannabinol 2022. 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