{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T17:39:17Z","timestamp":1787593157443,"version":"build-2736575974"},"reference-count":54,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,3,2]],"date-time":"2023-03-02T00:00:00Z","timestamp":1677715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2023,3,2]],"date-time":"2023-03-02T00:00:00Z","timestamp":1677715200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000133","name":"Agency for Healthcare Research and Quality","doi-asserted-by":"publisher","award":["K12HS026370"],"award-info":[{"award-number":["K12HS026370"]}],"id":[{"id":"10.13039\/100000133","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["K01DA055130"],"award-info":[{"award-number":["K01DA055130"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["UG1DA020024"],"award-info":[{"award-number":["UG1DA020024"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["UG1DA01581"],"award-info":[{"award-number":["UG1DA01581"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000016","name":"U.S. Department of Health and Human Services","doi-asserted-by":"publisher","award":["HHSN271201400028C"],"award-info":[{"award-number":["HHSN271201400028C"]}],"id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000016","name":"U.S. Department of Health and Human Services","doi-asserted-by":"publisher","award":["HHSN271201500065C"],"award-info":[{"award-number":["HHSN271201500065C"]}],"id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Socio\u2010cultural (gender) and biological (sex)\u2010based differences contribute to psychostimulant susceptibility, potentially affecting treatment responsiveness among women with methamphetamine use disorder (MUD). The aims were to measure (i) how women with MUD independently and compared with men respond to treatment versus placebo and (ii) among women, how the hormonal method of contraception (HMC) affects treatment responsiveness.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>This was a secondary analysis of ADAPT\u20102, a randomized, double\u2010blind, placebo\u2010controlled, multicenter, two\u2010stage sequential parallel comparison design trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>United States.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>This study comprised 126 women (403 total participants); average age\u2009=\u200940.1\u00a0years (standard deviation\u2009=\u20099.6) with moderate to severe MUD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interventions<\/jats:title>\n                    <jats:p>Interventions were combination intramuscular naltrexone (380\u2009mg\/3\u2009weeks) and oral bupropion (450\u2009mg daily) versus placebo.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements<\/jats:title>\n                    <jats:p>Treatment response was measured using a minimum of three of four negative methamphetamine urine drug tests during the last 2\u00a0weeks of each stage; treatment effect was the difference between weighted treatment responses of each stage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Findings<\/jats:title>\n                    <jats:p>\n                      At baseline, women used methamphetamine intravenously fewer days than men [15.4 versus 23.1% days,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.050, difference\u2009=\u2009\u22127.7, 95% confidence interval (CI)\u2009=\u2009\u221215.0 to \u22120.3] and more women than men had anxiety (59.5 versus 47.6%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.027, difference\u2009=\u200911.9%, 95% CI\u2009=\u20091.5\u00a0to\u00a022.3%). Of 113 (89.7%) women capable of pregnancy, 31 (27.4%) used HMC. In Stage 1 29% and Stage 2 5.6% of women on treatment had a response compared with 3.2% and 0% on placebo, respectively. A treatment effect was found independently for females and males (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001); with no between\u2010gender treatment effect (0.144\u2009females versus 0.100 males;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.363, difference\u2009=\u20090.044, 95% CI\u2009=\u2009\u22120.050 to 0.137). Treatment effect did not differ by HMC use (0.156 HMC versus 0.128 none;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.769, difference\u2009=\u20090.028, 95% CI \u22120.157 to 0.212).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Women with methamphetamine use disorder receiving combined intramuscular naltrexone and oral bupropion treatment achieve greater treatment response than placebo. Treatment effect does not differ by HMC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/add.16163","type":"journal-article","created":{"date-parts":[[2023,3,2]],"date-time":"2023-03-02T23:00:01Z","timestamp":1677798001000},"page":"1320-1328","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A gender\u2010based secondary analysis of the ADAPT\u20102 combination naltrexone and bupropion treatment for methamphetamine use disorder trial"],"prefix":"10.1111","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4919-7492","authenticated-orcid":false,"given":"Ximena A.","family":"Levander","sequence":"first","affiliation":[{"name":"Oregon Health and Science University, Department of Medicine, Division of General Internal Medicine and Geriatrics Addiction Medicine Section  Portland OR USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Carmody","sequence":"additional","affiliation":[{"name":"Department of Population and Data Sciences University of Texas Southwestern Medical Center  Dallas TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8754-995X","authenticated-orcid":false,"given":"Ryan R.","family":"Cook","sequence":"additional","affiliation":[{"name":"Oregon Health and Science University, Department of Medicine, Division of General Internal Medicine and Geriatrics Addiction Medicine Section  Portland OR USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer S.","family":"Potter","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences University of Texas Health Science Center San Antonio  San Antonio TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2983-1110","authenticated-orcid":false,"given":"Madhukar H.","family":"Trivedi","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Texas Southwestern Medical Center  Dallas TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5556-3597","authenticated-orcid":false,"given":"Philip Todd","family":"Korthuis","sequence":"additional","affiliation":[{"name":"Oregon Health and Science University, Department of Medicine, Division of General Internal Medicine and Geriatrics Addiction Medicine Section  Portland OR USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3583-0026","authenticated-orcid":false,"given":"Steven","family":"Shoptaw","sequence":"additional","affiliation":[{"name":"Department of Family Medicine University of California Los Angeles  Los Angeles CA USA"},{"name":"Department of Psychiatry and Biobehavioral Sciences University of California Los Angeles  Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,2]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"Executive Summary Policy Implications","author":"United Nations Office on Drugs and Crime (UNODC) Research","year":"2022"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)32230-5"},{"key":"e_1_2_9_4_1","volume-title":"2019 National Survey on Drug Use and Health","author":"Substance Abuse and Mental Health Services Administration (SAMHSA)","year":"2020"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2021.2588"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.2217\/17455057.4.1.51"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2019.01.017"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/02791072.2008.10400661"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2016.18.4\/jbecker"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1550-8579(08)80005-8"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1124\/pharmrev.121.000367"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2022.104674"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-016-1212-2"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-019-05276-2"},{"key":"e_1_2_9_16_1","first-page":"73","volume-title":"Biological Basis of Sex Differences in Psychopharmacology","author":"Anker JJ","year":"2011"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2010.04.003"},{"key":"e_1_2_9_18_1","unstructured":"HedegaardH Mini\u00f1oAM WarnerM MininoAM SpencerMR WarnerM.Drug overdose deaths in the United States 1999\u20132020. NCHS Data Brief no. 356. Hyattsville MD: National Center for Health Statistics;2020."},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.2019.305527"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41372-021-01271-8"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/add.15509"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ps.202100665"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2020.108193"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/add.14755"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2020214"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2019.3655"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/add.13950"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13293-022-00441-3"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsat.2007.05.011"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/adb.12395"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2014.10.013"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2013.05.007"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psc.2010.01.004"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jadohealth.2012.10.275"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1301481"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.2147\/SAR.S38902"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1177\/1740774507081217"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1080\/09595230801919486"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2007.01768.x"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1080\/00952990902968585"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.OLQ.0000430801.14841.75"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000000659"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsat.2010.08.011"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ypmed.2015.04.008"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11606-022-07558-6"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1097\/ADM.0000000000000471"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1097\/ADM.0000000000000021"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2022.05.010"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12954-020-00395-y"},{"key":"e_1_2_9_50_1","volume-title":"Key substance use and mental health indicators in the United States: results from the 2020 National Survey on Drug Use and Health","author":"Substance Abuse and Mental Health Services Administration (SAMHSA)","year":"2021"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12402-016-0208-3"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1097\/ADT.0b013e3182213ef1"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2020.0246"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/syn.21829"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2006.05.012"}],"container-title":["Addiction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/add.16163","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/add.16163","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/add.16163","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T17:16:34Z","timestamp":1787591794000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/add.16163"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,2]]},"references-count":54,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["10.1111\/add.16163"],"URL":"https:\/\/doi.org\/10.1111\/add.16163","archive":["Portico"],"relation":{},"ISSN":["0965-2140","1360-0443"],"issn-type":[{"value":"0965-2140","type":"print"},{"value":"1360-0443","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,2]]},"assertion":[{"value":"2022-09-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}