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A police education program (Proyecto Escudo) delivering training on occupational safety together with drug law content was implemented between 2015 and 2016 in Tijuana, Mexico, to underpin drug law reform implementation. We used data from a longitudinal cohort of PWID in Tijuana to inform epidemic modeling and assess the long\u2010term impact of Escudo on HCV transmission and burden among PWID in Tijuana.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We developed a dynamic, compartmental model of HCV transmission and incarceration among PWID and tracked liver disease progression among current and former PWID. The model was calibrated to data from Tijuana, Mexico, with 90% HCV seroprevalence. We used segmented regression analysis to estimate impact of Escudo on recent incarceration among an observational cohort of PWID. By simulating the observed incarceration trends, we estimated the potential impact of the implemented (2\u2010year reduction in incarceration) and an extended (10\u2010year reduction in incarceration) police education program over a 50\u2010year follow\u2010up (2016\u20132066) on HCV outcomes (incidence, cirrhosis, HCV\u2010related deaths and disability adjusted life\u2010years averted) compared with no intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Over the 2\u2010year follow\u2010up, Proyecto Escudo reduced HCV incidence among PWID from 21.5 per 100\u2009person\u2009years (\/100py) (95% uncertainty interval [UI] = 15.3\u201329.7\/100py) in 2016 to 21.1\/100py (UI = 15.0\u201329.1\/100py) in 2018. If continued for 10\u00a0years, Escudo could reduce HCV incidence to 20.0\/100py (14.0\u201327.8\/100py) by 2026 and avert 186 (32\u2013389) new infections, 76 (UI = 12\u2013160) cases of cirrhosis and 32 (5\u201373) deaths per 10\u2009000 PWID compared with no intervention over a 50\u2010year time horizon.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In Tijuana, Mexico, implementation of a police education program delivering training on occupational safety and drug law content appears to have reduced hepatitis C virus incidence among people who inject drugs.<\/jats:p>\n                  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