{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T02:00:29Z","timestamp":1789092029298,"version":"build-2803163510"},"reference-count":18,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T00:00:00Z","timestamp":1684454400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["17411960400"],"award-info":[{"award-number":["17411960400"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31800926"],"award-info":[{"award-number":["31800926"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31822025"],"award-info":[{"award-number":["31822025"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32071061"],"award-info":[{"award-number":["32071061"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008750","name":"Shanghai Hospital Development Center","doi-asserted-by":"publisher","award":["SHDC12018X19"],"award-info":[{"award-number":["SHDC12018X19"]}],"id":[{"id":"10.13039\/501100008750","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>Previous studies have focused on the role of perioperative nicotine replacement therapy (NRT) in improving the success rate of long\u2010term smoking cessation in tobacco smokers. This study aimed to measure the effectiveness of high\u2010dose NRT in alleviating postoperative pain for male abstinent smokers receiving abdominal surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>This was a parallel\u2010group, randomized, double\u2010blind and controlled pilot trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting and participants<\/jats:title><jats:p>In total, 101 male smoking\u2010abstinent patients from the Eastern Hepatobiliary Surgery Hospital, Shanghai, China, from 8 October 2018 to 10 December 2021.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interventions<\/jats:title><jats:p>Patients started smoking cessation on admission to the hospital ward. Patients received 24\u2010hour transdermal nicotine patches (<jats:italic>n<\/jats:italic>\u2009=\u200950) or placebo (<jats:italic>n<\/jats:italic>\u2009=\u200951) every day from admission until 48\u2009hours after surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements<\/jats:title><jats:p>The primary outcomes were pre\u2010surgery pain thresholds and total consumption of analgesics within the first 48\u2009hours after surgery. Secondary outcomes included postoperative pain and sedation scores, nausea, vomiting and fever frequency within the treatment period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Findings<\/jats:title><jats:p>Both pre\u2010surgery electrical and mechanical pain thresholds in the NRT group were higher than those in the placebo group (<jats:italic>P<\/jats:italic>\u2009=\u20090.004 and <jats:italic>P<\/jats:italic>\u2009=\u20090.020, respectively). The 48\u2010hour postoperative analgesic consumption was significantly lower for smoking\u2010abstinent patients receiving NRT than those receiving placebo (standardized morphine equivalent requirement, median [interquartile range], 1.80 [1.47, 2.32] mg\/kg vs 2.22 [1.62, 2.82] mg\/kg, <jats:italic>P<\/jats:italic>\u2009=\u20090.011). Postoperative pain intensity was significantly lower in the NRT group than that in the placebo group at 1st hour and 24th hour post\u2010surgery (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001 and <jats:italic>P<\/jats:italic>\u2009=\u20090.012, respectively). The incidence of treatment\u2010related adverse events was not significantly different between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Perioperative high\u2010dose nicotine replacement therapy may help to relieve postoperative pain among male smoking\u2010abstinent patients undergoing abdominal surgery.<\/jats:p><\/jats:sec>","DOI":"10.1111\/add.16224","type":"journal-article","created":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T06:17:55Z","timestamp":1683094675000},"page":"1579-1585","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Effect of perioperative high\u2010dose transdermal nicotine patch on pain sensitivity among male abstinent tobacco smokers undergoing abdominal surgery: A randomized controlled pilot study"],"prefix":"10.1111","volume":"118","author":[{"given":"Chengcheng","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Shanghai Eastern Hepatobiliary Surgery Hospital  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanzhi","family":"Bi","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Mental Health Institute of Psychology  Beijing China"},{"name":"Department of Psychology University of Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Shanghai Eastern Hepatobiliary Surgery Hospital  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunming","family":"Tao","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Shanghai Eastern Hepatobiliary Surgery Hospital  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Hu","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Mental Health Institute of Psychology  Beijing China"},{"name":"Department of Psychology University of Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0561-0591","authenticated-orcid":false,"given":"Zhijie","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Shanghai Eastern Hepatobiliary Surgery Hospital  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,19]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/add.16052"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.accpm.2017.02.002"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-022-06628-8"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD000146.pub5"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1037\/abn0000353"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addbeh.2017.10.024"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e3181bd1612"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e3182a8fa7b"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2017.02.019"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD013308"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.13578"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001874"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(02)00009-6"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2021.108515"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200412000-00023"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD009634.pub2"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1213\/ane.0b013e318163204f"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/add.14483"}],"container-title":["Addiction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/add.16224","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T21:36:31Z","timestamp":1692480991000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/add.16224"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,19]]},"references-count":18,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["10.1111\/add.16224"],"URL":"https:\/\/doi.org\/10.1111\/add.16224","archive":["Portico"],"relation":{},"ISSN":["0965-2140","1360-0443"],"issn-type":[{"value":"0965-2140","type":"print"},{"value":"1360-0443","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,19]]},"assertion":[{"value":"2022-12-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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