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However, little is known about how distinct risk factors influence each other and alcohol use on different temporal scales (within a given moment versus over time). We aimed to estimate the dynamic associations of distal (personality and life stressors) and proximal (drinking motives) risk factors, and their relationship to alcohol use in adolescence and early adulthood using a novel graphical vector autoregressive (GVAR) panel network approach.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design, setting and cases<\/jats:title><jats:p>We estimated panel networks on data from the IMAGEN study, a longitudinal European cohort study following adolescents across three waves (aged 16, 19 and 22\u2009years). Our sample consisted of 1829 adolescents (51% females) who reported alcohol use on at least one assessment wave.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements<\/jats:title><jats:p>Risk factors included personality traits (NEO\u2010FFI: neuroticism, extraversion, openness, agreeableness and conscientiousness; SURPS: impulsivity and sensation\u2010seeking), stressful life events (LEQ: sum scores of stressful life events), and drinking motives [drinking motives questionnaire (DMQ): social, enhancement, conformity, coping anxiety and coping depression]. We assessed alcohol use [alcohol use disorders identification test (AUDIT): quantity and frequency] and alcohol\u2010related problems (AUDIT: related problems).<\/jats:p><\/jats:sec><jats:sec><jats:title>Findings<\/jats:title><jats:p>Within a given moment, social [partial correlation (pcor)\u2009=\u20090.17] and enhancement motives (pcor\u2009=\u20090.15) co\u2010occurred most strongly with drinking quantity and frequency, while coping depression motives (pcor\u2009=\u20090.13), openness (pcor\u2009=\u20090.05) and impulsivity (pcor\u2009=\u20090.09) were related to alcohol\u2010related problems. The temporal network showed no predictive associations between distal risk factors and drinking motives. Social motives (beta\u2009=\u20090.21), previous alcohol use (beta\u2009=\u20090.11) and openness (beta\u2009=\u20090.10) predicted alcohol\u2010related problems over time (all <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Heavy and frequent alcohol use, along with social drinking motives, appear to be key targets for preventing the development of alcohol\u2010related problems throughout late adolescence. We found no evidence for personality traits and life stressors predisposing towards distinct drinking motives over time.<\/jats:p><\/jats:sec>","DOI":"10.1111\/add.16231","type":"journal-article","created":{"date-parts":[[2023,5,9]],"date-time":"2023-05-09T03:10:05Z","timestamp":1683601805000},"page":"1908-1919","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Drinking motives, personality traits and life stressors\u2014identifying pathways to harmful alcohol use in adolescence using a panel network approach"],"prefix":"10.1111","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9478-0575","authenticated-orcid":false,"given":"Ren\u00e9","family":"Freichel","sequence":"first","affiliation":[{"name":"Addiction Development and Psychopathology (ADAPT)\u2010lab, Department of Psychology University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7282-3899","authenticated-orcid":false,"given":"Janine","family":"Pfirrmann","sequence":"additional","affiliation":[{"name":"Addiction Development and Psychopathology (ADAPT)\u2010lab, Department of Psychology University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janna","family":"Cousijn","sequence":"additional","affiliation":[{"name":"Center for Substance Use and Addiction Research. 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