{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T19:14:46Z","timestamp":1760382886593,"version":"3.40.5"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T00:00:00Z","timestamp":1695686400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and aims<\/jats:title><jats:p>People with alcohol use disorder (AUD) often have co\u2010occurring psychiatric conditions. The association between psychiatric conditions and AUD relapse has not yet been fully explored. This study aimed to quantify different psychiatric comorbidities as risk factors for first and multiple AUD rehospitalizations in patients already hospitalized once for AUD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used a nation\u2010wide routine health\u2010care database in Scotland, UK, between 2010 and 2019. Individuals with a first hospitalization for AUD (codes F10.0\u20109 in the ICD\u201010 codes) were checked for previous hospitalizations where the main or co\u2010occurring cause was a psychiatric condition (any other F0\u2010F99 code in ICD\u201010). The final cohort included 23\u2009529 patients, 18\u2009620 of whom did not have a history of any other psychiatric comorbidity. First, individuals with a history of any previous psychiatric hospitalization were grouped and compared with those without on the basis of time to AUD rehospitalization. Then, individuals with different histories of psychiatric hospitalization were compared with each other. Cox and Prentice, Williams and Peterson gap\u2010time models were used for single and multiple AUD rehospitalizations, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The AUD rehospitalization rate in individuals with a previous psychiatric hospitalization was 8% higher compared with those without [hazard ratio (HR)\u2009=\u20091.08, 95% confidence interval (CI)\u2009=\u20091.01\u20131.14]. The difference in rehospitalization rate reduced following the first rehospitalization (HR at second rehospitalization from first: 0.95, 95% CI\u2009=\u20090.87\u20131.04 and HR at third rehospitalization from second: 0.94, 95% CI\u2009=\u20090.84\u20131.07). Mood disorders and neurotic, stress\u2010related and somatoform disorders were associated with a 54% (HR\u2009=\u20091.54, 95% CI\u2009=\u20091.38\u20131.72) and 39% (HR\u2009=\u20091.39, 95% CI\u2009=\u20091.17\u20131.66) increase in the risk of a first AUD rehospitalization. Other conditions, such as disorders due to psychoactive substance use or schizophrenia, were associated with decreases in future AUD rehospitalization (HR\u2009=\u20090.89, 95% CI\u2009=\u20090.82\u20130.97 and HR\u2009=\u20090.82, 95% CI\u2009=\u20090.58\u20131.16, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with AUD appear to have different rates of AUD rehospitalization based on different co\u2010occurring psychiatric conditions. Addiction\u2010related characteristics may be more relevant risk indicators for multiple AUD readmission than psychiatric comorbidities.<\/jats:p><\/jats:sec>","DOI":"10.1111\/add.16352","type":"journal-article","created":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T07:48:53Z","timestamp":1695714533000},"page":"291-300","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Previous psychiatric hospitalizations as risk factors for single and multiple future alcohol\u2010related hospitalizations in patients with alcohol use disorders"],"prefix":"10.1111","volume":"119","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2954-6774","authenticated-orcid":false,"given":"Francesco","family":"Manca","sequence":"first","affiliation":[{"name":"School of Health and Wellbeing University of Glasgow  Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3811-8165","authenticated-orcid":false,"given":"Jim","family":"Lewsey","sequence":"additional","affiliation":[{"name":"School of Health and Wellbeing University of Glasgow  Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,9,26]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1017\/S003329171000190X"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1369-1600.2006.00035.x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-020-09060-2"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2008.09.018"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2017.00134"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2018.00303"},{"key":"e_1_2_10_8_1","first-page":"81","article-title":"Comorbidity of alcoholism and psychiatric disorders: an overview","volume":"26","author":"Petrakis IL","year":"2002","journal-title":"Alcohol Res Health"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.14284"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11121-015-0624-1"},{"key":"e_1_2_10_11_1","first-page":"90","article-title":"Alcoholism and psychiatric disorders: diagnostic challenges","volume":"26","author":"Shivani R","year":"2002","journal-title":"Alcohol Res Health"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.15288\/jsad.2016.77.849"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2006.01310.x"},{"key":"e_1_2_10_14_1","first-page":"129","article-title":"Psychiatric disorders associated with alcoholism: 2 year follow\u2010up of treatment","volume":"40","author":"Sanchez\u2010Pena JF","year":"2012","journal-title":"Actas Esp Psiquiatr"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2019.05.038"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2005.11.005"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40621-019-0215-x"},{"volume-title":"General Acute Inpatient and Day Case\u2013Scottish Morbidity Record (SMR01)","year":"2020","author":"Public Health Scotland","key":"e_1_2_10_18_1"},{"volume-title":"The ICD\u201010 classification of mental and behavioural disorders: clinical descriptions and diagnostic guidelines","year":"1992","author":"World Health Organization","key":"e_1_2_10_19_1"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9780511790942"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyw060"},{"key":"e_1_2_10_22_1","unstructured":"National Institute of Health and Care Excellence (NICE).Alcohol Dependence. 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