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This systematic review measured the effectiveness of culturally tailoring smoking cessation interventions on quitting or reducing smoking combustible tobacco.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We searched MEDLINE, PsychInfo, Embase and Cochrane Central Register from inception to 21 June 2023 for randomized controlled trials (RCTs) of community\u2010based, primary care or web\u2010based interventions for smoking cessation in adults who smoked tobacco, with measurement of smoking abstinence or reduction at least 3\u00a0months following baseline. We examined comparisons between either an intensity\u2010matched culturally tailored intervention and a non\u2010tailored intervention or a standard non\u2010tailored intervention and the same intervention plus a culturally tailored adjunct. We sub\u2010grouped studies according to the level of tailoring and performed subgroup analyses where appropriate. We assessed risk of bias and certainty of evidence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 43 studies, 33 of which were meta\u2010analyzed (<jats:italic>n<\/jats:italic>\u2009=\u200912\u2009346 participants). We found moderate certainty evidence, limited by heterogeneity, that intensity\u2010matched culturally tailored cessation interventions increased quit success when compared with non\u2010tailored interventions at 3\u2010month follow\u2010up or longer (<jats:italic>n<\/jats:italic>\u2009=\u20095602, risk ratio [RR]\u2009=\u20091.29 95% confidence interval [CI] 1.10, 1.51, I<jats:sup>2<\/jats:sup>\u00a0=\u200947%, 14 studies). We found a positive effect of adding a culturally tailored component to a standard intervention compared with the standard intervention alone (<jats:italic>n<\/jats:italic>\u2009=\u20096674, RR\u2009=\u20091.47, 95% CI 1.10, 1.95, I<jats:sup>2<\/jats:sup>\u00a0=\u200974%, 18 studies), but our certainty in this effect was low due to imprecision and substantial statistical heterogeneity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Culturally tailored smoking cessation interventions may help more people to quit smoking than a non\u2010tailored intervention. Adapting or adding cultural components to smoking cessation interventions originally developed for majority populations could improve cessation rates in populations who do not fully identify with majority cultural norms.<\/jats:p><\/jats:sec>","DOI":"10.1111\/add.16400","type":"journal-article","created":{"date-parts":[[2023,12,18]],"date-time":"2023-12-18T02:35:26Z","timestamp":1702866926000},"page":"629-648","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Effectiveness of culturally tailoring smoking cessation interventions for reducing or quitting combustible tobacco: A systematic review and meta\u2010analyses"],"prefix":"10.1111","volume":"119","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2014-9032","authenticated-orcid":false,"given":"Andrea","family":"Leinberger\u2010Jabari","sequence":"first","affiliation":[{"name":"Public Health Research Center New York University Abu Dhabi  Abu Dhabi United Arab 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