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Our study aimed to measure the consequences of this new practice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design, setting and participants<\/jats:title><jats:p>This was a retrospective cohort study set in Switzerland\u2019s largest outpatient centre for opioid agonist therapy. One hundred and thirty\u2010four (72.4%) of the 185 patients receiving oral diacetylmorphine (DAM) participated in the study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements<\/jats:title><jats:p>Through the utilization of electronic medication prescription and dispensing software, as well as the electronic medical record, the following data were extracted to explore the potential consequences: dose of DAM, the number of antibiotic therapies, emergency hospitalizations and incarcerations. Age, gender, prescriptions for psychotrophic drugs and additional prescription for injectable DAM were tested to assess an increased risk of losing prolonged take\u2010home privileges. Data in the year since prolonged take\u2010home (period 2) were compared with data from the equivalent prior year (period 1).<\/jats:p><\/jats:sec><jats:sec><jats:title>Findings<\/jats:title><jats:p>DAM take\u2010home was not associated with a change in DAM dose (<jats:italic>P<\/jats:italic>\u2009=\u20090.548), the number of emergency hospitalizations (<jats:italic>P<\/jats:italic>\u2009=\u20090.186) or the number of incarcerations (<jats:italic>P<\/jats:italic>\u2009=\u20090.215); 79.1% of all patients were able to maintain their extended take\u2010home privileges. However, patients who had injectable DAM experienced significant reductions in their prolonged take\u2010home privileges.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Allowing patients to take home oral diacetylmorphine for up to 7\u00a0days as treatment for opioid use disorder does not appear to pose any demonstrable health risk. It is generally manageable for the large majority of patients. However, careful consideration of prolonged take\u2010home for patients with additional injectable diacetylmorphine is recommended, as these patients are more likely to lose take\u2010home privileges.<\/jats:p><\/jats:sec>","DOI":"10.1111\/add.16503","type":"journal-article","created":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T06:43:11Z","timestamp":1713768191000},"page":"1421-1429","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Prolonged diacetylmorphine take\u2010home during the COVID\u201019 pandemic\u2014Results of a retrospective cohort study"],"prefix":"10.1111","volume":"119","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6246-0788","authenticated-orcid":false,"given":"Franciska","family":"Brezan","sequence":"first","affiliation":[{"name":"Arud Centre for Addiction Medicine  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1183-1195","authenticated-orcid":false,"given":"Maximilian","family":"Meyer","sequence":"additional","affiliation":[{"name":"Psychiatric University Clinics Basel University of Basel  Basel Switzerland"},{"name":"Department of Psychiatry, Faculty of Medicine University of British Columbia  Vancouver Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Vogel","sequence":"additional","affiliation":[{"name":"Psychiatric University Clinics Basel University of Basel  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakob","family":"Heimer","sequence":"additional","affiliation":[{"name":"Department of Mathematics, Seminar for Statistics ETH Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Falcato","sequence":"additional","affiliation":[{"name":"Arud Centre for Addiction Medicine  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Montagna","sequence":"additional","affiliation":[{"name":"Arud Centre for Addiction Medicine  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Bruggmann","sequence":"additional","affiliation":[{"name":"Arud Centre for Addiction Medicine  Zurich Switzerland"},{"name":"Institute of Primary Care, University Hospital Zurich University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)06529-1"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2009.02741.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.114.149195"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000259173"},{"key":"e_1_2_9_6_1","unstructured":"SchaubM BolligerH HiltebrandD.Heroingest\u00fctzte Behandlung\u2014Ver\u00e4nderung der Klientel in der Schweiz und Review der Kostenanalysen Schlussbericht [Heroin\u2010assisted treatment\u2014change in the clientele in Switzerland and review of the cost analyses final report]. 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