{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T20:22:07Z","timestamp":1787602927264,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T00:00:00Z","timestamp":1716336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T00:00:00Z","timestamp":1716336000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and aims<\/jats:title>\n                    <jats:p>Studies on cancer incidence and mortality among people with opioid use\u2010related disorders are lacking. We aimed to measure cancer\u2010specific incidence, mortality and survival among people diagnosed with opioid use\u2010related disorders in Norway during 2010\u201318.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design and setting<\/jats:title>\n                    <jats:p>This was a cohort study conducted in Norway during 2010\u201318.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>\n                      Individuals (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200920\u00a0710) diagnosed with opioid use\u2010related disorders.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements<\/jats:title>\n                    <jats:p>We conducted a cohort study utilizing a data\u2010linkage of national health and population registers. Information on opioid use\u2010related disorders was extracted from specialized healthcare, malignancies from the Cancer Registry of Norway and deaths from Cause of Death Registry. Cancer incidence and mortality were compared with the general population by calculating sex\u2010specific age\u2010standardized incidence (SIR) and mortality (SMR) ratios. One\u2010year survival rates were computed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Findings<\/jats:title>\n                    <jats:p>Compared with the general population, people with opioid use\u2010related disorders were at an increased risk of developing cancer overall [SIR\u2009=\u20091.2, 95% confidence interval (CI)\u2009=\u20091.1\u20131.3] with a higher than twofold cancer mortality rate (SMR\u2009=\u20092.3, 95% CI\u2009=\u20092.0\u20132.7). Excess risk was observed for liver (12.6, 95% CI\u2009=\u20099.1\u201317.0), larynx (4.7, 95% CI\u2009=\u20091.7\u201310.2), lung (3.5, 95% CI\u2009=\u20092.8\u20134.3) and pancreas cancer (2.6, 95% CI\u2009=\u20091.6\u20134.0), whereas reduced risk was found for melanoma (0.5, 95% CI\u2009=\u20090.3\u20130.9), breast (0.6, 95% CI\u2009=\u20090.4\u20130.9) and prostate cancers (0.3, 95% CI\u2009=\u20090.1\u20130.4). Site\u2010specific SMRs were significantly elevated for liver (12.3, 95% CI\u2009=\u20098.5\u201317.2), lung (3.9, 95% CI\u2009=\u20093.0\u20135.0), pancreas (3.0, 95% CI\u2009=\u20091.7\u20134.8) and colon cancers (1.9, 95% CI\u2009=\u20091.1\u20133.1). The average 1\u2010year survival rate after a cancer diagnosis was low in liver, pancreas and colon cancer, ranging from 10 to 15% less than that of the general population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In Norway, cancer incidence and cancer\u2010related mortality appear to be elevated among individuals with opioid use\u2010related disorders.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/add.16524","type":"journal-article","created":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T06:44:41Z","timestamp":1716360281000},"page":"1575-1584","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Increased cancer incidence and mortality among people with opioid use\u2010related disorders: A nation\u2010wide cohort study"],"prefix":"10.1111","volume":"119","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7037-1363","authenticated-orcid":false,"given":"Emil","family":"Kostovski","sequence":"first","affiliation":[{"name":"Manifestsenteret  R\u00f8yken Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksi","family":"Hamina","sequence":"additional","affiliation":[{"name":"Niuvanniemi Hospital  Kuopio Finland"},{"name":"Norwegian Centre for Addiction Research (SERAF), Institute of Clinical Medicine University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vidar","family":"Hjellvik","sequence":"additional","affiliation":[{"name":"Department of Chronic Diseases, Division of Mental and Physical Health The Norwegian Institute of Public Health  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2421-4201","authenticated-orcid":false,"given":"Thomas","family":"Clausen","sequence":"additional","affiliation":[{"name":"Norwegian Centre for Addiction Research (SERAF), Institute of Clinical Medicine University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svetlana","family":"Skurtveit","sequence":"additional","affiliation":[{"name":"Norwegian Centre for Addiction Research (SERAF), Institute of Clinical Medicine University of Oslo  Oslo Norway"},{"name":"Department of Chronic Diseases, Division of Mental and Physical Health The Norwegian Institute of Public Health  Oslo 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