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This study reports on the previously unpublished stage 2 MA use in participants randomized at stage 1 to receive NTX\u2009+\u2009BUPN through both stages compared with those assigned to placebo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>This is a secondary analysis of the US National Institute on Drug Abuse (NIDA) ADAPT\u20102 network trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>The parent ADAPT\u20102 trial was carried out across multiple NIDA Clinical Trials Network (CTN) sites in the United States.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>This analysis includes 403 people with MA use disorder who participated in the ADAPT\u20102 CTN trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Intervention and comparator<\/jats:title><jats:p>NTX\u2009+\u2009BUPN was compared with placebo over the course of the trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurement<\/jats:title><jats:p>MA use was measured by urine drug screens conducted twice weekly for 12\u2009weeks, then once in week 13 and once in week 16 post\u2010treatment follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Findings<\/jats:title><jats:p>Participants on NTX\u2009+\u2009BUPN in stage 1 showed an additional 9.2% increase [95% confidence interval (CI),\u00a00.09%\u201317.9%, <jats:italic>P<\/jats:italic>\u2009=\u20090.038]\u00a0during stage 2 in their probability of testing negative for MA, with a total increase of 27.1% (95% CI, 13.2%\u201341.1%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) over the full 12\u2009weeks of treatment. In contrast, participants on placebo in both stages increased in probability of testing MA\u2010negative by a total of 11.4% (95% CI, 4.1%\u201318.6%, <jats:italic>P<\/jats:italic>\u2009=\u20090.002) over all 12\u2009weeks. The 12\u2010week increase among participants on NTX\u2009+\u2009BUPN was significantly greater\u2014by 15.8% (95% CI, 4.5%\u201327.0%, <jats:italic>P<\/jats:italic>\u2009=\u20090.006)\u2014than the increase among those on placebo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>For people with methamphetamine (MA) use disorder receiving treatment with extended\u2010release injectable naltrexone plus extended\u2010release oral bupropion (NTX\u2009+\u2009BUPN), continued treatment with NTX + BUPN after 6\u00a0weeks is associated with additional reductions in MA use up to 12\u2009weeks.<\/jats:p><\/jats:sec>","DOI":"10.1111\/add.16529","type":"journal-article","created":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T12:00:44Z","timestamp":1718020844000},"page":"1840-1845","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Extended observation of reduced methamphetamine use with combined naltrexone plus bupropion in the ADAPT\u20102 trial"],"prefix":"10.1111","volume":"119","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2457-604X","authenticated-orcid":false,"given":"Michael J.","family":"Li","sequence":"first","affiliation":[{"name":"Center for Behavioral and Addiction Medicine University of California, Los Angeles  Los Angeles California USA"},{"name":"Department of Family Medicine University of California, Los Angeles  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brendon","family":"Chau","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Fielding School of Public Health University of California, Los Angeles  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Belin","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Fielding School of Public Health University of California, Los Angeles  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Carmody","sequence":"additional","affiliation":[{"name":"Center for Depression Research and Clinical Care, Department of Psychiatry University of Texas, Southwestern Medical Center  Dallas Texas USA"},{"name":"Peter O'Donnell Jr. School of Public Health University of Texas, Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manish K.","family":"Jha","sequence":"additional","affiliation":[{"name":"Center for Depression Research and Clinical Care, Department of Psychiatry University of Texas, Southwestern Medical Center  Dallas Texas USA"},{"name":"O'Donnell Brain Institute University of Texas, Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elise N.","family":"Marino","sequence":"additional","affiliation":[{"name":"Center for Depression Research and Clinical Care, Department of Psychiatry University of Texas, Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2983-1110","authenticated-orcid":false,"given":"Madhukar","family":"Trivedi","sequence":"additional","affiliation":[{"name":"Center for Depression Research and Clinical Care, Department of Psychiatry University of Texas, Southwestern Medical Center  Dallas Texas USA"},{"name":"O'Donnell Brain Institute University of Texas, Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3583-0026","authenticated-orcid":false,"given":"Steven J.","family":"Shoptaw","sequence":"additional","affiliation":[{"name":"Center for Behavioral and Addiction Medicine University of California, Los Angeles  Los Angeles California USA"},{"name":"Department of Family Medicine University of California, Los Angeles  Los Angeles California USA"},{"name":"Department of Psychiatry and Biobehavioral Sciences University of California, Los Angeles  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,10]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"United Nations Office on Drugs and Crime.Drug market trends: cocaine amphetamine\u2010type stimulants new psychoactive substances. 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