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Participants (<jats:italic>n<\/jats:italic>\u2009=\u200996, 60.4% female, age mean\u2009=\u200921.7 [standard deviation\u2009=\u20091.7] years, 82.4% white race) were identified via their participation in a cohort study or other convenience sampling and were 18 to 25\u2009years old, vaped \u22654\u00a0days\/week for \u22654\u00a0weeks and used other tobacco products for \u22645\u00a0days of past 30\u2009days. Participants completed a pre\u2010vaping questionnaire, vaped their usual brand of e\u2010cigarette ad libitum for 30\u2009min and completed a post\u2010vaping questionnaire.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements<\/jats:title><jats:p>Outcome variables included pre\u2010 and post\u2010vaping measures of plasma nicotine (t\u2009=\u20090 and t\u2009=\u200930, respectively) and craving and withdrawal symptoms, as well as vaping topography (e.g. flow rate and inter\u2010puff interval), pre\u2010vaping expectancies and post\u2010vaping product appeal. Variables used to characterize the sample included demographics, e\u2010cigarette and other tobacco use history, e\u2010cigarette dependence and e\u2010cigarette device characteristics (e.g. device type, flavor and nicotine form).<\/jats:p><\/jats:sec><jats:sec><jats:title>Findings<\/jats:title><jats:p>Participants reported moderate nicotine dependence on average via the E\u2010Cigarette Dependence Scale (mean\u2009=\u20096.9 [standard deviation\u2009=\u20094.0]). Following 30\u2009min of ad libitum vaping, participants achieved substantial plasma nicotine boost (mean\u2009=\u200918.8 [standard deviation\u2009=\u200914.5] ng\/mL), corresponding with statistically significant decreases in withdrawal symptoms measured via the Minnesota Nicotine Withdrawal Scale (pre\u2010vaping mean\u2009=\u20099.0 [standard deviation\u2009=\u20095.1], post\u2010vaping mean\u2009=\u20094.3 [standard deviation\u2009=\u20093.9]; <jats:italic>P<\/jats:italic>\u2010value &lt;0.0001). Pre\u2010vaping, participants reported moderate vaping expectancies (e.g. mean\u2009=\u20092.5 [standard deviation\u2009=\u20091.0] on a scale from 0 to 4 for smell and taste expectancies); post\u2010vaping, participants reported high satisfaction (mean\u2009=\u20094.6 [standard deviation\u2009=\u20091.2] on a scale from 1 to 7) and moderate reward (mean\u2009=\u20092.9 [standard deviation\u2009=\u20091.2]) and respiratory sensations (mean\u2009=\u20093.7 [standard deviation\u2009=\u20091.6]). Nearly half of participants (47.9%) used disposable e\u2010cigarettes, and most used a mint\/menthol or fruit flavored (99.0%) and nicotine salt (98.9%) e\u2010liquid.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Among young adults in the United States, the latest generations of e\u2010cigarettes appear to deliver large quantities of nicotine (similar to cigarettes) and significantly relieve withdrawal symptoms, and they are appealing.<\/jats:p><\/jats:sec>","DOI":"10.1111\/add.16531","type":"journal-article","created":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T09:34:38Z","timestamp":1716802478000},"page":"503-513","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["An observational human laboratory assessment of nicotine delivery, vaping topography and subjective effects of usual brand electronic cigarette use among young adults"],"prefix":"10.1111","volume":"120","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8574-7263","authenticated-orcid":false,"given":"Brittney","family":"Keller\u2010Hamilton","sequence":"first","affiliation":[{"name":"Division of Medical Oncology, Department of Internal Medicine The Ohio State University College of Medicine  Columbus Ohio USA"},{"name":"Center for Tobacco Research The Ohio State University Comprehensive Cancer Center  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Sloan","sequence":"additional","affiliation":[{"name":"Center for Tobacco Research The Ohio State University Comprehensive Cancer Center  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toral","family":"Mehta","sequence":"additional","affiliation":[{"name":"Center for Tobacco Research The Ohio State University Comprehensive Cancer Center  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Hinton","sequence":"additional","affiliation":[{"name":"Center for Tobacco Research The Ohio State University Comprehensive Cancer Center  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alayna P.","family":"Tackett","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, Department of Internal Medicine The Ohio State University College of Medicine  Columbus Ohio USA"},{"name":"Center for Tobacco Research The Ohio State University Comprehensive Cancer Center  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4743-2145","authenticated-orcid":false,"given":"Megan E.","family":"Roberts","sequence":"additional","affiliation":[{"name":"Center for Tobacco Research The Ohio State University Comprehensive Cancer Center  Columbus Ohio USA"},{"name":"Division of Health Behavior and Health Promotion The Ohio State University College of Public Health  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marielle C.","family":"Brinkman","sequence":"additional","affiliation":[{"name":"Center for Tobacco Research The Ohio State University Comprehensive Cancer Center  Columbus Ohio USA"},{"name":"Division of Epidemiology The Ohio State University College of Public Health  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4028-0081","authenticated-orcid":false,"given":"Theodore L.","family":"Wagener","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, Department of Internal Medicine The Ohio State University College of Medicine  Columbus Ohio USA"},{"name":"Center for Tobacco Research The Ohio State University Comprehensive Cancer Center  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2019.5436"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/tobaccocontrol-2014-051540"},{"key":"e_1_2_10_4_1","unstructured":"U.S. Food & Drug Administration.FDA finalizes enforcement policy on unauthorized flavored cartridge\u2010based e\u2010cigarettes that appeal to children including fruit and mint.U.S. Department of Health and Human Services;2020.https:\/\/www.fda.gov\/news-events\/press-announcements\/fda-finalizes-enforcement-policy-unauthorized-flavored-cartridge-based-e-cigarettes-appeal-children. 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