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Participants were164 adults with methamphetamine dependence, reporting at least 14 use days out of the previous 28\u2009days (62% male, 38% female, &lt;\u20091% other; mean age 39\u2009years).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interventions<\/jats:title>\n                    <jats:p>\n                      Participants were randomly allocated 1:1 to a 15\u2010week regimen of lisdexamfetamine (1\u2010week induction to 250\u2009mg, 12\u2010week maintenance regimen, 2\u2010week reduction;\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200980) or matched placebo (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200984), followed\u2010up to Week 19.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements<\/jats:title>\n                    <jats:p>The primary efficacy measure was past 28\u2010day methamphetamine use at Week 13. Safety was assessed by adverse event rates. Secondary measures included methamphetamine use during the 12\u2010week treatment period and treatment satisfaction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Findings<\/jats:title>\n                    <jats:p>\n                      Nine randomized participants did not start treatment (five were allocated to lisdexamfetamine and four allocated to placebo) and were excluded from the analyses. Fifty\u2010seven per cent of participants were retained on study medication to primary end\u2010point. There was only weak evidence of a lisdexamfetamine benefit at 13\u2009weeks [adjusted difference in days of methamphetamine use\u2009=\u20092.2, 95% confidence interval (CI)\u2009=\u2009\u20130.5 to\u00a05.0;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.49]. However, throughout the whole 12\u2010week treatment maintenance phase, the lisdexamfetamine group had fewer days of methamphetamine use in total (difference\u2009=\u20098.8, 95% CI\u2009=\u20092.7\u201315.0;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.005). The lisdexamfetamine group reported greater self\u2010reported treatment effectiveness [odds ratio (OR)\u2009=\u20092.89, 95% CI\u2009=\u20091.67\u20135.02;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001] and treatment satisfaction (OR\u2009=\u20093.80, 95% CI\u2009=\u20091.93\u20137.47;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). Adverse events with lisdexamfetamine included nausea. Serious adverse events occurred in four (5%) of participants who received lisdexamfetamine.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Lisdexamfetamine appears to reduce methamphetamine use over a 12\u2010week treatment period, although there is only weak evidence that reduced use is maintained during the last 4\u2009weeks.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/add.16730","type":"journal-article","created":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T19:01:06Z","timestamp":1734634866000},"page":"1345-1359","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Lisdexamfetamine in the treatment of methamphetamine dependence: A randomised, placebo\u2010controlled 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