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This study aimed to gather insights on how people use or are considering using psychedelics to manage opioid use disorder (OUD), how these experiences are perceived to impact opioid use and what these lessons imply for future research and practice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a qualitative study using the Reddit online community platform. We extracted posts that contained key psychedelic terms from the two most subscribed\u2010to subreddits dedicated to discussions of OUD treatment (r\/OpiatesRecovery and r\/Methadone) from 2018 to 2021. We thematically analyzed content from 151 relevant posts and their respective comments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two prominent themes identified in discussions were perspectives on the effectiveness of psychedelics in treating OUD, and mechanisms through which psychedelics were thought to impact use and desire to use opioids. For many, psychedelics were deemed to have a strong impact on opioid use via multiple mechanisms, including alleviating physical symptoms of dependence, shifting motivations around desire to use opioids and addressing underlying mental health problems and reasons for use. Others saw the potential promise around psychedelics as exaggerated, acknowledging many people eventually return to use, or even considered psychedelics dangerous.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There appear to be diverse perspectives on the effects of using psychedelics to treat opioid use disorder and an urgent need for controlled studies to better understand the impact of different psychedelics on opioid use, how they may be used in the context of existing treatments and what strategies they must be combined with to ensure safety and effectiveness. Integrating the experiences of people who use drugs will help guide psychedelics research toward effective person\u2010centered interventions to enhance health and wellness.<\/jats:p><\/jats:sec>","DOI":"10.1111\/add.16767","type":"journal-article","created":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T02:44:07Z","timestamp":1737081847000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Self\u2010reported experiences and perspectives on using psychedelics to manage opioid use among participants of two Reddit communities"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7396-3938","authenticated-orcid":false,"given":"Noa","family":"Krawczyk","sequence":"first","affiliation":[{"name":"Department of Population Health NYU Grossman School of Medicine  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Population Health NYU Grossman School of Medicine  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma Yuanqi","family":"Gu","sequence":"additional","affiliation":[{"name":"Rady School of Management University of California San Diego  La Jolla CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Irvine","sequence":"additional","affiliation":[{"name":"Department of Population Health NYU Grossman School of Medicine  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisbel","family":"Ramirez","sequence":"additional","affiliation":[{"name":"Department of Population Health NYU Grossman School of Medicine  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Santaella\u2010Tenorio","sequence":"additional","affiliation":[{"name":"Departamento de Salud P\u00fablica y Epidemiolog\u00eda Pontificia Universidad Javeriana  Cali Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Lippincott","sequence":"additional","affiliation":[{"name":"Center for Language and Speech Processing Johns Hopkins University  Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4530-3470","authenticated-orcid":false,"given":"Michael","family":"Bogenschutz","sequence":"additional","affiliation":[{"name":"Department of Psychiatry NYU Grossman School of Medicine; 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