{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T18:36:12Z","timestamp":1774550172809,"version":"3.50.1"},"reference-count":44,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T00:00:00Z","timestamp":1762387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T00:00:00Z","timestamp":1762387200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To examine the socioeconomic differences in the effectiveness of alcohol use disorders (AUD) pharmacotherapy and risk of AUD hospitalisation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>A prospective register\u2010based cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Sweden.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>\n                      Individuals who were registered as living in Sweden in 2005 (16\u201364\u2009years) with a first\u2010time AUD diagnosis and complete information on their socioeconomic position (SEP) between 2005 and 2019 (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009148\u2009626).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurement<\/jats:title>\n                    <jats:p>The outcome was AUD hospitalisation. The use of AUD pharmacotherapy was treated as a time\u2010varying exposure. SEP was the moderator. The association between the joint\u2010exposure (pharmacotherapy use and SEP) and AUD hospitalisation was assessed using a competing\u2010risk regression model, adjusted for sociodemographic factors, previous mental health diagnoses and use of other psychiatric medications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Findings<\/jats:title>\n                    <jats:p>Pharmacotherapy use was associated with a lower risk of AUD hospitalisation among high SEP individuals [subdistribution hazard ratio (SHR) = 0.83, 95% confidence interval (CI) = 0.77\u20130.90], but not among those with low SEP (SHR = 1.02, 95% CI = 0.94\u20131.10) and middle SEP (SHR = 1.01, 95% CI = 0.94\u20131.09), compared with low SEP individuals when not using pharmacotherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In Sweden, alcohol use disorder (AUD) pharmacotherapy appears to be effective to reduce the risk of AUD hospitalisation only among individuals of high socioeconomic position.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/add.70238","type":"journal-article","created":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T01:43:27Z","timestamp":1762479807000},"page":"597-605","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Socio\u2010economic differences in the effectiveness of pharmacotherapy use in alcohol use disorder: A cohort study of 148\u2009626 individuals in Sweden"],"prefix":"10.1111","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4452-8080","authenticated-orcid":false,"given":"Devy L.","family":"Elling","sequence":"first","affiliation":[{"name":"Unit of Occupational Medicine Institute of Environmental Medicine, Karolinska Institutet  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emelie","family":"Thern","sequence":"additional","affiliation":[{"name":"Unit of Occupational Medicine Institute of Environmental Medicine, Karolinska Institutet  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Llu\u00eds","family":"Mangot\u2010Sala","sequence":"additional","affiliation":[{"name":"Unit of Occupational Medicine Institute of Environmental Medicine, Karolinska Institutet  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jari","family":"Tiihonen","sequence":"additional","affiliation":[{"name":"Centre for Psychiatry Research, Department of Clinical Neuroscience Karolinska Institutet  Stockholm Sweden"},{"name":"Department of Forensic Psychiatry University of Eastern Finland, Niuvanniemi Hospital  Kuopio Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders","family":"Hammarberg","sequence":"additional","affiliation":[{"name":"Centre for Psychiatry Research, Department of Clinical Neuroscience Karolinska Institutet  Stockholm Sweden"},{"name":"Stockholm Health Care Services, Region Stockholm  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4441-7003","authenticated-orcid":false,"given":"Daniel","family":"Falkstedt","sequence":"additional","affiliation":[{"name":"Unit of Occupational Medicine Institute of Environmental Medicine, Karolinska Institutet  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heidi","family":"Taipale","sequence":"additional","affiliation":[{"name":"Department of Forensic Psychiatry University of Eastern Finland, Niuvanniemi Hospital  Kuopio Finland"},{"name":"Division of Insurance Medicine, Department of Clinical Neuroscience Karolinska Institutet  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,6]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"World Health Organization.Global status report on alcohol and health and treatment of substance use disorders. Geneva: World Health Organization; 2024."},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S285936"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-2667(20)30052-9"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/add.15567"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001909"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/dar.12448"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-015-1720-7"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/add.15070"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/add.13834"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/add.15213"},{"key":"e_1_2_10_12_1","unstructured":"Ramboll.The societal consequences of alcohol [Alkoholens samh\u00e4llskonsekvenser].2019."},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)00847-9"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2019-029184"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/10550887.2020.1724606"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/add.15357"},{"key":"e_1_2_10_17_1","first-page":"48","article-title":"An overview of pharmacotherapy options for alcohol use disorder","author":"Carpenter JE","year":"2018","journal-title":"Fed Pract"},{"key":"e_1_2_10_18_1","unstructured":"Swedish National Board of Health and Welfare.National guidelines for treatment and support for abuse and addiction [Nationella riktlinjer f\u00f6r v\u00e5rd och st\u00f6d vid missbruk och beroende].2019."},{"issue":"6","key":"e_1_2_10_19_1","first-page":"768","article-title":"The added value of pharmacotherapy to cognitive behavior therapy and vice versa in the treatment of alcohol use disorders: A systematic review","volume":"57","author":"Amsterdam J","year":"2022","journal-title":"Alcohol Alcohol"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.19761"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/add.15384"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.11406"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2022.05.016"},{"key":"e_1_2_10_24_1","article-title":"Barriers to treatment for alcohol dependence","volume":"8","author":"May C","year":"2019","journal-title":"J Drug Alcohol Res"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/14550725221082512"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13690-023-01085-4"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/ADM.0000000000000918"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/agq089"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2021.108964"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11205-018-1871-x"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsat.2018.10.009"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/agt067"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00420-021-01697-9"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1017\/S003329172100060X"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.1294"},{"key":"e_1_2_10_36_1","unstructured":"Swedish National Board of Health and Welfare.Guidelines for coding use and abuse of alcohol [Anvisningar f\u00f6r kodning av bruk och missbruk av alkohol]. Stockholm: Swedish National Board of Health and Welfare;2016."},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwm324"},{"key":"e_1_2_10_38_1","unstructured":"World Health Organization.ATC\/DDD Index 2023. 2023 [cited 2023 Jun 12]. Available from:https:\/\/www.whocc.no\/atc_ddd_index\/"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0174426"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1360-0443.1999.94686710.x"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1136\/jech.2004.023531"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1515\/em-2013-0005"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13722-024-00471-9"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0184070"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/add.16456"}],"container-title":["Addiction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/add.70238","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/add.70238","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/add.70238","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T08:20:57Z","timestamp":1772958057000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/add.70238"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,6]]},"references-count":44,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1111\/add.70238"],"URL":"https:\/\/doi.org\/10.1111\/add.70238","archive":["Portico"],"relation":{},"ISSN":["0965-2140","1360-0443"],"issn-type":[{"value":"0965-2140","type":"print"},{"value":"1360-0443","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,6]]},"assertion":[{"value":"2024-12-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}