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We argue that no\/lo drinks may have an important role to play for people who drink at high\u2010risk levels and those with alcohol use disorders (AUD) or alcohol\u2010related liver disease (ARLD), particularly where debate and guidance related to treatment of these problems considers goals other than abstinence. The limited available evidence available suggests no\/lo drinks may be useful in supporting attempts to reduce alcohol consumption or maintain abstinence among high\u2010risk drinkers who do not have severe AUD or ARLD; however, they may also entail significant risks of relapse in those recovering from AUD. We therefore need further experimental and longitudinal studies testing whether use of no\/lo drinks can lead to, or support, reductions in alcohol consumption. We particularly need high\u2010quality experimental studies to test whether exposure to and sustained use of no\/lo drinks affects treatment and recovery outcomes. Evidence is also needed on which subgroups of AUD and ARLD patients would benefit or be at risk from use of either alcohol\u2010free or low\u2010alcohol drinks. Finally, guidance should recognise that many patients already use these products and that a zero\u2010tolerance approach may alienate patients or erode trust in clinicians.<\/jats:p>","DOI":"10.1111\/add.70244","type":"journal-article","created":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T07:45:01Z","timestamp":1762760701000},"page":"1036-1041","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Zero tolerance for 0%? How should clinicians and other practitioners respond to the use of alcohol\u2010free and low\u2010alcohol products in higher risk groups"],"prefix":"10.1111","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9283-2151","authenticated-orcid":false,"given":"John","family":"Holmes","sequence":"first","affiliation":[{"name":"School of Medicine and Population Health University of Sheffield  Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4934-8345","authenticated-orcid":false,"given":"Christopher K.","family":"Oldroyd","sequence":"additional","affiliation":[{"name":"National Institute for Health and Care Research (NIHR) Cambridge Biomedical Research Centre  Cambridge UK"},{"name":"Cambridge Liver Unit Cambridge University Hospitals NHS Foundation Trust  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin","family":"Drummond","sequence":"additional","affiliation":[{"name":"National Addiction Centre, Institute of Psychiatry, Psychology and Neuroscience King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7790-5559","authenticated-orcid":false,"given":"Matt","family":"Field","sequence":"additional","affiliation":[{"name":"School of Psychology University of Sheffield, Interdisciplinary Centre of the Social Sciences (ICOSS) Building  Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inge","family":"Kersbergen","sequence":"additional","affiliation":[{"name":"School of Medicine and Population Health University of Sheffield  Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael E. 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