{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:04:20Z","timestamp":1787616260961,"version":"build-2736575974"},"reference-count":62,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T00:00:00Z","timestamp":1762732800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T00:00:00Z","timestamp":1762732800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100016658","name":"Plan Nacional sobre Drogas","doi-asserted-by":"publisher","award":["PNSD2017|039"],"award-info":[{"award-number":["PNSD2017|039"]}],"id":[{"id":"10.13039\/100016658","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016658","name":"Plan Nacional sobre Drogas","doi-asserted-by":"publisher","award":["PNSD2021|075"],"award-info":[{"award-number":["PNSD2021|075"]}],"id":[{"id":"10.13039\/100016658","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016658","name":"Plan Nacional sobre Drogas","doi-asserted-by":"publisher","award":["PR2014"],"award-info":[{"award-number":["PR2014"]}],"id":[{"id":"10.13039\/100016658","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To identify the brain activity profiles associated with alcohol consumption and to address its causes. Furthermore, we sought to examine the relationship between these electrophysiological markers and the excitation\u2013inhibition balance, as well as to explore the potential moderating role of sex in these associations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Longitudinal study involving a neuroimaging assessment that included magnetoencephalography (MEG) and magnetic resonance imaging (MRI), along with a battery of self\u2010report questionnaires. A follow\u2010up assessment was conducted two years later using the same set of neuroimaging and behavioural measures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting and participants<\/jats:title>\n                    <jats:p>56 adolescents aged 13 to 17\u2009years recruited from high schools in the community of Madrid, Spain, prior to the initiation of alcohol use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements<\/jats:title>\n                    <jats:p>We extracted measures of power spectral density and excitation\u2013inhibition balance across the brain from MEG recordings and cognitive traits related to risk behaviors from a battery of self\u2010report questionnaires. Alcohol consumption was evaluated during the follow\u2010up visit through structured individual interviews.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Findings<\/jats:title>\n                    <jats:p>\n                      Power\u2010spectra in beta\u2010band showed a positive correlation with alcohol use during both stages (baseline: rho\u2009=\u00a00.33,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05; follow\u2010up: rho\u2009=\u00a00.35;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05) and a negative correlation with excitation\u2013inhibition ratio (baseline:\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001; rho\u2009=\u2009\u22120.56; follow\u2010up:\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.01; rho\u2009=\u2009\u22120.37). Finally, biological sex showed strong moderation effect, where females drove the predictive relationship (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001; rho\u2009=\u00a00.64; \u03b2\u2009=\u2009\u22120,61).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Spontaneous electrophysiological brain activity may provide an early biomarker of future alcohol use in females and appears to be associated with activity profiles prone to inhibition.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/add.70246","type":"journal-article","created":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T09:52:03Z","timestamp":1762768323000},"page":"606-616","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Electrophysiological sexual dimorphism as an early risk marker of alcohol use in adolescence: A longitudinal neuroimaging study"],"prefix":"10.1111","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0630-0373","authenticated-orcid":false,"given":"Alberto","family":"del Cerro\u2010Le\u00f3n","sequence":"first","affiliation":[{"name":"Centre of Cognitive and Computational Neuroscience Universidad Complutense de Madrid (UCM)  Madrid Spain"},{"name":"Department of Experimental Psychology, Cognitive Processes and Speech Therapy Universidad Complutense de Madrid (UCM)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos","family":"Uceta","sequence":"additional","affiliation":[{"name":"Centre of Cognitive and Computational Neuroscience Universidad Complutense de Madrid (UCM)  Madrid Spain"},{"name":"Department of Cellular Biology, Faculty of Biology Complutense University of Madrid (UCM)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danylyna","family":"Shpakivska\u2010Bilan","sequence":"additional","affiliation":[{"name":"Centre of Cognitive and Computational Neuroscience Universidad Complutense de Madrid (UCM)  Madrid Spain"},{"name":"Department of Experimental Psychology, Cognitive Processes and Speech Therapy Universidad Complutense de Madrid (UCM)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Su\u00e1rez\u2010M\u00e9ndez","sequence":"additional","affiliation":[{"name":"Centre of Cognitive and Computational Neuroscience Universidad Complutense de Madrid (UCM)  Madrid Spain"},{"name":"Department of Experimental Psychology, Cognitive Processes and Speech Therapy Universidad Complutense de Madrid (UCM)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9ctor","family":"Perib\u00e1\u00f1ez\u2010Baz","sequence":"additional","affiliation":[{"name":"Centre of Cognitive and Computational Neuroscience Universidad Complutense de Madrid (UCM)  Madrid Spain"},{"name":"Department of Experimental Psychology, Cognitive Processes and Speech Therapy Universidad Complutense de Madrid (UCM)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Cuesta","sequence":"additional","affiliation":[{"name":"Centre of Cognitive and Computational Neuroscience Universidad Complutense de Madrid (UCM)  Madrid Spain"},{"name":"Health Research Institute of the Hospital Cl\u00ednico San Carlos (IdISSC)  Madrid Spain"},{"name":"Department of Radiology Complutense University of Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Bru\u00f1a","sequence":"additional","affiliation":[{"name":"Centre of Cognitive and Computational Neuroscience Universidad Complutense de Madrid (UCM)  Madrid Spain"},{"name":"Department of Radiology Complutense University of Madrid  Madrid 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