{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T18:47:38Z","timestamp":1783536458568,"version":"3.55.0"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T00:00:00Z","timestamp":1763510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T00:00:00Z","timestamp":1763510400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and aims<\/jats:title>\n                    <jats:p>Heated tobacco products (HTPs) are increasingly used by individuals attempting to quit smoking, particularly in Japan where HTP use is prevalent; however, the effectiveness of HTPs in achieving complete tobacco abstinence remains unclear. This study aimed to estimate the likelihood of complete tobacco abstinence and combustible cigarette abstinence among exclusive HTP users and dual users compared with exclusive combustible cigarette users.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>A prospective cohort design using sequential annual follow\u2010ups (2019\u20132023) from the Japan \u2018Society and New Tobacco\u2019 Internet Survey (JASTIS). Inverse probability\u2010weighted Poisson generalized estimating equation models were used to estimate rate ratios for abstinence outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Nationwide internet\u2010based survey conducted in Japan.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>A total of 8969 Japanese adults aged 20\u2009years and older who were current tobacco users at baseline were included. Participants were categorized as exclusive combustible cigarette users (55.6%), exclusive HTP users (16.3%) or dual users (28.0%). Exclusive HTP users were further categorized as established (daily use, \u2265100 HTPs used, or &gt;12\u2009months of lifetime use) or non\u2010established users.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements<\/jats:title>\n                    <jats:p>Primary outcomes were (1) complete tobacco abstinence\u2014defined as no current use of any tobacco products used at baseline\u2014and (2) combustible cigarette abstinence after one year. Abstinence required selecting \u201cused regularly in the past but quit\u201d for each relevant product.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Findings<\/jats:title>\n                    <jats:p>Compared with exclusive combustible cigarette users (as classified at baseline), the rate ratio (RR) for complete tobacco abstinence was 0.85 [95% confidence interval (CI) = 0.71\u20131.02] among exclusive HTP users and 0.49 (95% CI = 0.42\u20130.58) among dual users. When stratified, established HTP users had a statistically significantly lower likelihood of complete tobacco abstinence (RR = 0.57, 95% CI = 0.47\u20130.70), while non\u2010established users showed a higher likelihood (RR = 2.41, 95% CI = 1.83\u20133.17). Compared with exclusive combustible cigarette users, the RR for combustible cigarette abstinence after one year was 0.93 (95% CI = 0.83\u20131.04) among dual users.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this one\u2010year follow\u2010up, dual use of cigarettes and heated tobacco products (HTP) and established exclusive HTP use were associated with lower rates of complete tobacco abstinence compared with exclusive cigarette use, while non\u2010established exclusive HTP use showed higher abstinence rates. Overall, HTP use was not associated with higher tobacco abstinence rates.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/add.70257","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T04:05:46Z","timestamp":1763611546000},"page":"970-981","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Heated tobacco product use and tobacco abstinence: A prospective cohort study"],"prefix":"10.1111","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0764-0110","authenticated-orcid":false,"given":"Tomohiko","family":"Ukai","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Clinical Research The Research Institute of Tuberculosis  Kiyose Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3395-9691","authenticated-orcid":false,"given":"Tomohiro","family":"Shinozaki","sequence":"additional","affiliation":[{"name":"Interfaculty Initiative in Information Studies The University of Tokyo  Bunkyo\u2010ku Japan"},{"name":"Department of Biostatistics, School of Public Health, Graduate School of Medicine the University of Tokyo  Bunkyo\u2010ku Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1050-3125","authenticated-orcid":false,"given":"Takahiro","family":"Tabuchi","sequence":"additional","affiliation":[{"name":"Division of Epidemiology, School of Public Health Tohoku University Graduate School of Medicine  Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,19]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ntr\/ntx138"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/tobaccocontrol-2020-056257"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/add.16199"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanepe.2021.100159"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/tobaccocontrol-2018-054419"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2017.1419"},{"key":"e_1_2_12_8_1","article-title":"Heated tobacco products for smoking cessation and reducing smoking prevalence","volume":"1","author":"Tattan\u2010Birch H","year":"2022","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_12_9_1","unstructured":"Center for Tobacco Products.FDA authorizes reduced exposure claim for IQOS 3 system holder and charger [Internet]. U.S. Food and Drug Administration FDA;2022[cited 2025 Jul 6]. Available from:https:\/\/www.fda.gov\/tobacco-products\/ctp-newsroom\/fda-authorizes-reduced-exposure-claim-iqos-3-system-holder-and-charger"},{"key":"e_1_2_12_10_1","unstructured":"WHO Study Group on Tobacco Product Regulation.WHO study group on tobacco product regulation: report on the scientific basis of tobacco product regulation: eighth report of a WHO study group. Geneva (Switzerland): World Health Organization;2021[cited 2024 Jun 2]. Available from:https:\/\/www.who.int\/publications\/i\/item\/9789240022720"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.2188\/jea.JE20210075"},{"key":"e_1_2_12_12_1","unstructured":"TabuchiT.Effects of the widespread use of heated tobacco products on the monitoring of tobacco use status and smoking cessation practices in Japan. Wako (Japan): National Institute of Public Health; 2019. 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